Both studies met their primary endpoints and all key secondary endpoints, demonstrating a statistically significant and clinically meaningful effect on weight loss and reductions in insatiable hunger, or hyperphagia
, in patients with POMC and LEPR deficiency obesities.
The primary endpoint is change from baseline hyperphagia
score at Week 13.
Saniona added that based on the positive effects seen in the first part of the study in adult patients with PWS, it remains confident that Tesomet holds the potential to treat debilitating hyperphagia
and significantly reduce weight in this severely underserved population.
In the Smiths-Magenis syndrome (SMS), presenting in late childhood/adolescence with hyperphagia
and dysmorphism, a point mutation in RAI1, which is a transcription factor involved in craniofacial and neural development, is implicated (10).
The bears are currently in hyperphagia
, a period of time when they are constantly eating to fatten themselves up for hibernation, a spokesperson for Colorado Parks and Wildlife said.
(12,24) In anorexic patients, hyposalivation may occur during prolonged periods of fasting; in the case of bulimic patients, this decrease is observed due to the rapid swallowing of food during the bouts of hyperphagia
Other characteristic manifestations include impaired satiety, intense hyperphagia
, a normal birth weight and rapid weight gain during early infancy (1).
On Day 10 of his stay on the pediatric unit, because of the emergence of hypersexuality and hyperphagia
, along with a largely negative medical evaluation, Mr.
Currently, bears are in hyperphagia
, which is a period when the animals were constantly eating to fatten themselves up before hibernation, a spokesperson for Colorado Parks and Wildlife said in a report.
The company's lead asset, livoletide, is an unacylated ghrelin analogue being developed for the treatment of Prader-Willi syndrome, a rare genetic disease characterised by hyperphagia
, a chronic unrelenting hunger, that leads to obesity, metabolic dysfunction, reduced quality of life and early mortality.
In animal models, it was revealed that maternal obesity adversely impacted the offspring, evident by hyperphagia
, adiposity, dyslipidemia, hepatic steatosis, insulin resistance, and hypertension [71-73].
In this model, adult offspring have higher total body fat and visceral fat despite a mild hyperphagia
, suggesting that they are hypometabolic.