11) With activation of the GABA receptor, potentiation of the transmembrane chloride conduction
hyperpolarizes the postsynaptic cell membrane resulting in functional inhibition of neurons.
Bumetanide reduces GDP event frequency and
hyperpolarizes neurons to decrease the depolarizing driving force for GABA.
It is able to shorten the action potential duration in both PV and LA cells but significantly
hyperpolarizes the resting membrane potential and increases dV/[dt.
ions by activating BK channels which
hyperpolarizes the membrane and causes relaxation [149].
Tizanidine is an alpha-2 adrenergic agonist that
hyperpolarizes moto neurons and decreases the release of excitatory amino acids and its side effects include nausea, vomiting, hypotension, sedation, and hepatotoxicity.
Its activation
hyperpolarizes terminals, thereby deactivating voltagegated [Ca.
19) Electrophysiological studies have shown that GABAB receptors in the VTA
hyperpolarizes dopamine neurons.
This action
hyperpolarizes the neurons and muscle fibers, leading to flaccid paralysis and insect death (Cully et al.
Hypokalemia
hyperpolarizes the skeletal muscle cells impairing their ability to develop the depolarization, which is necessary for muscle contraction.
EDHF is thought to be a cytochrome P450-derived arachidonic acid metabolite that
hyperpolarizes vascular smooth muscle cells by opening [Ca.
Subsequent activation causes a chloride influx that
hyperpolarizes the membrane, making the cell less excitable.
