11) With activation of the GABA receptor, potentiation of the transmembrane chloride conduction hyperpolarizes
the postsynaptic cell membrane resulting in functional inhibition of neurons.
Bumetanide reduces GDP event frequency and hyperpolarizes
neurons to decrease the depolarizing driving force for GABA.
It is able to shorten the action potential duration in both PV and LA cells but significantly hyperpolarizes
the resting membrane potential and increases dV/[dt.
ions by activating BK channels which hyperpolarizes
the membrane and causes relaxation .
Tizanidine is an alpha-2 adrenergic agonist that hyperpolarizes
moto neurons and decreases the release of excitatory amino acids and its side effects include nausea, vomiting, hypotension, sedation, and hepatotoxicity.
Its activation hyperpolarizes
terminals, thereby deactivating voltagegated [Ca.
19) Electrophysiological studies have shown that GABAB receptors in the VTA hyperpolarizes
This action hyperpolarizes
the neurons and muscle fibers, leading to flaccid paralysis and insect death (Cully et al.
the skeletal muscle cells impairing their ability to develop the depolarization, which is necessary for muscle contraction.
EDHF is thought to be a cytochrome P450-derived arachidonic acid metabolite that hyperpolarizes
vascular smooth muscle cells by opening [Ca.
Subsequent activation causes a chloride influx that hyperpolarizes
the membrane, making the cell less excitable.