hyperpolarize

(redirected from hyperpolarizing)
Also found in: Medical.
Related to hyperpolarizing: depolarizing

hy·per·po·lar·ize

 (hī′pər-pō′lə-rīz′)
tr.v. hy·per·po·lar·ized, hy·per·po·lar·iz·ing, hy·per·po·lar·iz·es
To cause an increase in polarity, as across a biological membrane.

hyperpolarize

(ˌhaɪpəˈpəʊləˌraɪz) or

hyperpolarise

vb (tr)
(Biology) biology physics to cause increased polarization
References in periodicals archive ?
The cones contact both depolarizing bipolar cells (DBCs) and hyperpolarizing bipolar cells (HBCs) through sign-inverting (−) synapses (ON synapse) and sign-preserving (+) synapses (OFF synapse), respectively.
On the other hand, the activation and inactivation V 1/2 values of the two channels had a reduction towards a hyperpolarizing shift caused by CGA under PGE2 pretreatment.
However, the experiments performed to elucidate whether the endothelium-derived hyperpolarizing factor EDHF could play a role in the vasorelaxant effect to clobenzorex, as previously reported for acetyl-choline (32,33), are discussed below.
Furthermore, Leutscher-Hazelhoff (1984) recorded hyperpolarizing photic responses from the radiolar photoreceptors of A.
To investigate the mechanisms involved in CGA-induced relaxation, the contribution of nitric oxide synthase (NOS), cyclooxy-genase (COX) and the endothelium-derived hyperpolarizing factor (EDHF) was assessed in endothelium-intact aortic rings preincubated with the NOS inhibitor, N[omega]-nitro-L-arginine methyl ester (L-NAME, [10.
ATP]) on the [beta]-cell membrane and inhibit a hyperpolarizing efflux of [K.
The relaxing effect of Thyme on corpus cavernosal tissue could be mediated by multiple action mechanisms including increasing the release of nitric oxide from corporal sinusoids, increasing the intracellular calcium sequestration that hyperpolarizing action [28].
As a possible mechanism, the authors proposed that high level of depolarization of neurons during the full-blown seizures activated the hyperpolarizing potassium currents, which suppressed the depolarizing influence of ionic currents.
13, 14) It decreases the concentration of angiotensin II and hence endothelin, increases the concentration of bradykinin, which is a vasodilator and stimulator of NO, endothelial derived hyperpolarizing factor and prostacyclin, and decreases superoxide anion concentration.
Intrathecal alpha-2 adrenoceptor agonists act by depressing the release of C-fiber transmitters and by hyperpolarizing postsynaptic dorsal horn neurons.
Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in mice.
For instance, FHM1 mutations in Cacna1a exhibit greater hyperpolarizing shifts in voltage-dependence when expressed in the short ([Ca.