In fact, a widely appreciated theory, the hygiene theory, advances that as a society's social-economic conditions and hygiene improves, the immune system becomesincreasingly hyperresponsive
to harmless environmental substances resultingin various allergic conditions such as asthma.
Beyond their core role in necrosis, the necrosome components RIP1 and RIP3 have been proposed to be hyperresponsive
to the induction of assembly, which were applied to the NLRP3 inflammasome.
Wistar Kyoto (WKY) rats, a high-anxiety strain considered to be hyperresponsive
to stress, are also a recognized animal model of impaired gastric accommodation [108, 109].
A serum-induced arthritis model involving [Dicer.sup.d/d] mice (Dicer1-deficient mice) was used in the same study to further confirm that dysregulated biogenesis of total miRNAs is also along with a hyperresponsive
inflammatory reaction in FLS from RA mice.
Furthermore, Ben-Sasson, Soto, Martinez-Pedraza, and Carter (2013) found a relationship between the hyperresponsive
behavior patterns of children with autism, disruptions in their families' daily routines, and parental stress.
The gingiva often becomes hyperresponsive
to mildest microbial deposits, leading to greater periodontal destruction, making such patients more vulnerable to periodontal destruction.
We hypothesized that the state of immunosuppression by blunting antigen-specific response in HIV-infected patients might be a key factor in preventing hyperresponsive
innate immune storm that leads to severe ocular involvements in SJS/TEN patients.
ACC and insula may be hyperresponsive
to asthma-specific emotional and afferent physiological signals, which may contribute to the dysregulation of peripheral processes .
This SNP consists of a single-base change resulting in a substitution of Arg to Trp in the 620 position at P1 domain of the phosphatase, which plays an important role in the interaction to Csk kinase in order to downregulate the activation signaling pathway, causing by this an hyperresponsive
T and B cell phenotype .
In addition, stressed mice not only have a higher number of circulating cells (leukocytes and platelets) but also have bigger, reticulated, and hyperresponsive
platelets as previously reported in human studies [35, 44-46], which suggest modification in bone marrow milieu.
Hand et al., "Aquaporin 5-deficient mouse lungs are hyperresponsive
to cholinergic stimulation," Proceedings of the National Academy of Sciences of the United States of America, vol.
sensory patterns in young children with autism, developmental delay, and typical development," American Journal on Intellectual and Developmental Disabilities, vol.