Notably, lineages IIa and IIb have the greatest overlap with the putatively hypervirulent
clade 8 (34), making their segregation of particular concern.
Ultrasonography showed submental and liver abscesses which were subsequently drained and both cultures isolated KP with hypermucoid colonies on agar plate and a positive string test indicating the presence of this new hypervirulent
strain of KP.
strain causes efficient sporulation and high-level resistance to fluoroquinolones, the antibiotics commonly used in treating CDI, and higher mortality rates.
8,9) Furthermore, some hypervirulent
strains have been documented in patients from Latin America (9) including Mexico, (8,10) although their clinical relevance is uncertain.
An investigation after their deaths found that a hypervirulent
strain of the bacteria Klebsiella pneumoniae was what killed them.
MGIAs also allow efficacy against different strains (including hypervirulent
strains) to be tested in parallel in cells from the same animal, rather than limiting to one laboratory strain, which may be unrepresentative of clinical strains affecting humans, as for in vivo challenge.
Clinical and phenotypic differences between classic and hypervirulent
Klebsiella pneumonia: an emerging and under-recognized pathogenic variant.
The emergence and spread of the hypervirulent
, fluoroquinolone-resistant, ribotype 027 strain of C.
difficile transmission, identifying multidrug-resistant PCR ribotype 027 strains in foods in 2004 was of concern because of their emergence as hypervirulent
in Europe and North America [7-9].
10) In fact, extensive rearrangement of multiple genetic factors and phage integration gave rise to a hypervirulent
serotype M23 strain of GAS.
Shon AS, Bajwa RP, Russo TA, Hypervirulent
(hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed.
difficile which also revealed the presence of mutant hypervirulent
strain, NAP1/BI/027 (North American Pulse-field gel electrophoresis type 1/restriction endonuclease analysis BI/ribotype 027) has been described in a study.