With recent funding from the National Institutes of Health under a program to fund high-risk, high-reward research, Russo and his UB colleagues are studying the microbiology of the new variant of Klebsiella pneumoniae in an effort to identify the genes that make it hypervirulent
so they can figure out how to stop it in its tracks.
The recurrence rate was found to be similar between fidaxomicin and vancomycin among patients infected with the NAP1/BI/027 strain (the hypervirulent
"North American" strain).
During the early 2000s, a hypervirulent
NAP1 (North American pulsed-field gel electrophoresis type 1) C.
difficile, higher duration of diarrhea, a greater risk of diarrhea, and higher frequency of hypervirulent
027 strains than other groups.
Only CDI cases caused by hypervirulent
strains (ribotype 027) have been reported in Costa Rica and Chile but most likely this is underdiagnosed.
tuberculosis (1) Hypervirulent
strain promotes alternative macrophage activation in the absence of IFN-[gamma] that controls bacterial replication (2) Dampens antibacterial [20, 41, 42, IL-1[beta] production, IL-10 98, 105-107] downstream of type I IFNs reduces antibacterial activity of IFN-[gamma]; causes fatal inflammation due to increased chemokine production, neutrophil recruitment to the lung, and alveolar macrophage death S.
The emergence and spread of the hypervirulent
, fluoroquinolone-resistant, ribotype 027 strain of C.
The researchers analysed the full genome of the "hypervirulent
" strains and an older strain.
-- Clostridium difficile ribotype 078 is an emerging hypervirulent
strain increasingly implicated in the sharp surge in community-acquired C.
Since the 1990s, pyogenic liver abscesses caused by specific hypervirulent
strains of Klebsiella pneumoniae have emerged as a major epidemiologic problem in Southeast Asia and now represent >80% of pyogenic liver abscesses in Asia (11,14,15).
First report of hypervirulent
strains polymerase chain reaction ribotypes 027 and 078 causing severe Clostridium difficile infection in Italy.