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See orexin.

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Its exact cause is unclear though scientists have found in certain studies that it is a product of low hypocretin levels, with patients having 95 percent less of it than those who do not have the disorder. 
A hormone called hypocretin, produced in the brain structure called the hypothalamus and known to have a role in the regulation of sleep, was found to play an unexpected role in controlling white blood cell production.
The MGH team found that hypocretin regulates production of white blood cells through interaction with neutrophil progenitors in the bone marrow.
The etiology of EDS in PD includes change of sleep-wake regulation, side effect of dopamine agonist treatment, poor sleep quality at night, genetic factors, male gender, disease duration, disease stage, hypocretin level, benzodiazepines, autonomic dysfunction, and depression.[3] The EDS in patients with PD can be diagnosed by clinical history, scales (Epworth Sleepiness Scale [ESS] and Inappropriate Sleep Composite Score), actigraphy, PSG, and the Multiple Sleep Latency Test/Maintenance of Wakefulness Test.
While sleep is organized by some complex mechanisms in hypothalamus and brain stem, many neurotransmitters such as serotonin, adenosine, histamine, hypocretin, norepinephrine-gamma-aminobutyric acid, norepinephrine and epinephrine are involved in the process (1).
Yokogawa et al., "Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons," Neuron, vol.
Indeed, CD200R1 and CD200R1L (CD200R2) are receptors for CD200 whilst HCRTR2 is a hypocretin (orexin) receptor 2 implicated in neuropeptide signaling pathway [7].
It is thought to be related with disruption in hypocretin secretion as a result of autoimmune damage in cells that secrete hypocretin (orexin) in the lateral hypothalamus.
Genetic ablation of hypocretin neurons alters behavioral state transitions in zebrafish.
Global Markets Direct's, 'Orexin Receptor Type 2 (Ox2R or Hypocretin Receptor Type 2 or HCRTR2) - Pipeline Review, H1 2016', provides in depth analysis on Orexin Receptor Type 2 (Ox2R or Hypocretin Receptor Type 2 or HCRTR2) targeted pipeline therapeutics.