The high-risk variants were most common in the high-risk leukemia subtype hypodiploid
A study by Perry et al (23) demonstrated cytogenetic abnormalities of a near diploid clone with loss of chromosomes 3 and 14 in one FDCS case and a hypodiploid
clone with loss of chromosomes 5, 6, 9, 14, 16, and 22 in another FDCS case.
Karyotyping revealed hypodiploid
karyotype and deletion of 13q with the following details: 41-45, XX,-2,add(12)(p11),der(13)t(2;13)(p10;q10),del(13q),del(14)(q24),add(19)(p13),add(20)(p13),-22[CP5]/48,XX,+X,+X,del(11)(p13).
1] phases, and hypodiploid
cells (cells under death process) were analized.
In this study, EVO inhibited the viability of the A2780, A2780CP, SKOV-3, and ES-2 human ovarian cancer cell lines with increased apoptotic characteristics such as DNA ladders, caspase-3 and PARP cleavage and hypodiploid
ZnONP enhanced a rapid induction of nuclear condensation, DNA fragmentation, and the formation of hypodiploid
DNA-containing nuclei and apoptotic bodies .
In the literature, hypodiploid
chromosome numbers were found in 3-10% of adults and 1-7% of childhood ALL.
The resulting percentages of apoptotic cells were determined as the percentages of hypodiploid
cells (sub G0/G1 peaks).
and hyperdiploid karyotypes were defined as having <45 and >46 chromosomes, respectively.
As shown in Figure 3B, the specific inactivation of DR4/DR5 receptors caused a 50% reduction in the amount of hypodiploid
cells, as observed after Pcy treatment (Figures 2A and 3A).
Genetic aberrations in hypodiploid
breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene.
In the hybrid hypodiploid
metaphase spreads, two intact sets of H.