hypodiploid


Also found in: Medical.

hypodiploid

(ˌhaɪpəʊˈdɪplɔɪd)
adj
(Medicine) med having fewer chromosomes than the diploid number
References in periodicals archive ?
The high-risk variants were most common in the high-risk leukemia subtype hypodiploid ALL.
A study by Perry et al (23) demonstrated cytogenetic abnormalities of a near diploid clone with loss of chromosomes 3 and 14 in one FDCS case and a hypodiploid clone with loss of chromosomes 5, 6, 9, 14, 16, and 22 in another FDCS case.
Karyotyping revealed hypodiploid karyotype and deletion of 13q with the following details: 41-45, XX,-2,add(12)(p11),der(13)t(2;13)(p10;q10),del(13q),del(14)(q24),add(19)(p13),add(20)(p13),-22[CP5]/48,XX,+X,+X,del(11)(p13).
In this study, EVO inhibited the viability of the A2780, A2780CP, SKOV-3, and ES-2 human ovarian cancer cell lines with increased apoptotic characteristics such as DNA ladders, caspase-3 and PARP cleavage and hypodiploid cells.
ZnONP enhanced a rapid induction of nuclear condensation, DNA fragmentation, and the formation of hypodiploid DNA-containing nuclei and apoptotic bodies [132].
In the literature, hypodiploid chromosome numbers were found in 3-10% of adults and 1-7% of childhood ALL.
The resulting percentages of apoptotic cells were determined as the percentages of hypodiploid cells (sub G0/G1 peaks).
As shown in Figure 3B, the specific inactivation of DR4/DR5 receptors caused a 50% reduction in the amount of hypodiploid cells, as observed after Pcy treatment (Figures 2A and 3A).
Genetic aberrations in hypodiploid breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene.