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n. hipofibrinogenemia, contenido bajo de fibrinógeno en la sangre.
English-Spanish Medical Dictionary © Farlex 2012
References in periodicals archive ?
However, 2 weeks later, fever returned, along with splenomegaly, hemodynamic instability, pancytopenia, hypofibrinogenemia, hyperferritinemia, and elevated soluble CD25.
Since he suffered from fevers, seizures, hepatosplenomegaly, anemia, thrombocytopenia, hypertriglyceridemia, and hypofibrinogenemia, he was diagnosed with HLH.
A patient with acute fatty liver of pregnancy who presented with acute hepatic and renal failure along with a hypofibrinogenemia was noted to have bleeding after vaginal delivery by vacuum extraction.
Fever (39[degrees]C), bicytopenia (hemoglobin, 8.8 g/dL) thrombocytopenia (88 x 1[0.sup.9]/L), hypofibrinogenemia (1.44 g/L), and high ferritin (1019 ng/ml) were compatible with the criteria used in the HLH-2004 trial (3).
Acute decrease in hematocrit, increase in serum lipase levels, hypofibrinogenemia, hypoxemia, thrombocytopenia (50% of patients), anemia (70% of patients), and hypocalcemia (due to free fatty acid binding to calcium) typically occur, if present, at the same time as clinical manifestations (24-72 hours after initial insult).24,32 Although these laboratory findings frequently occur in the settings of FES, they are not specific.
The patient met diagnostic criteria for HLH, including fever, splenomegaly, cytopenia, hypertriglyceridemia, hypofibrinogenemia, hemophagocytosis in bone marrow, and elevated ferritin.
Some patients may develop thrombocytopenia, anemia, or even hypofibrinogenemia. Cytological examination of the urine and sputum may show fat globules, but their diagnostic role still remains controversial.
Alternative modified criteria have been proposed, with at least 3 out of 4 clinical manifestations (fever, splenomegaly, cytopenias of minimum 2 lines, and hepatitis) and at least 1 out of 4 laboratory criteria (hemophagocytosis, hyperferritinemia, increased soluble IL2 (CD25) receptor, and absent or very decreased NK function), with hypertriglyceridemia, hypofibrinogenemia, and hyponatremia supporting the diagnosis [9].
The diagnosis of HLH must be based on clinical and laboratory criteria, according to the 2004 guidelines of the Histiocyte Society, which include continuous fever, lymphadenopathy and hepatosplenomegaly, cytopenias that affect at least two or three cell lineages, hypertriglyceridemia and/or hypofibrinogenemia, hemophagocytosis, low NK-cell activity, hyperferritinemia, and high soluble interleukin-2-receptor (soluble CD25) levels (5).