idiotype


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Related to idiotype: isotype, allotype

id·i·o·type

 (ĭd′ē-ə-tīp′)
n.
The complete set of idiotopes contained within the variable region of a particular immunoglobulin molecule and making up the molecule's antigen binding site.

id′i·o·typ′ic (-tĭp′ĭk) adj.
id′i·o·ty′py (-tī′pē) n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

idiotype

(ˈɪdɪəʊˌtaɪp)
n
the unique part of an antibody
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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Chertov et al., "Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens," International Immunology, vol.
(2003) Idiotype - antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
Moshfegh et al., "Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients," Clinical Cancer Research, vol.
Therapeutic strategies using tumor-specific immunoglobulin (idiotype, Id) for lymphomas are promising.
These vaccines include Allovectin-7 and OncoVEX, for the treatment of Melanoma, BiovaxId (Idiotype vaccine therapy) for follicular non-Hodgkin lymphoma, and GV1001 for advanced pancreatic cancer.
In some instances, some antibodies, called idiotype antibodies, act as antigens, triggering an immune response similar to that described above.
Phase II trial of idiotype vaccination in previously treated patients with indolent non-Hodgkin's lymphoma resulting in durable clinical responses.
In an accompanying editorial, "Idiotype vaccination in follicular lymphoma: knocking on the doorway to a cure," Dr.
The topics include the purification of primary malignant B-cells and immunoblot analysis of Bcl-2 family proteins, idiotype gene rescue in follicular lymphoma, and antibody techniques used to study anaplastic lymphoma kinase-positive ALCL.
But now compare the idiotype represented by hypothetical Genotype A.