Chertov et al., "Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype
and carrier antigens," International Immunology, vol.
- antiidiotypic relationship of neurotropic autoantibodies in patients with mild closed head injury.
Moshfegh et al., "Long-term idiotype
vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients," Clinical Cancer Research, vol.
Therapeutic strategies using tumor-specific immunoglobulin (idiotype
, Id) for lymphomas are promising.
These vaccines include Allovectin-7 and OncoVEX, for the treatment of Melanoma, BiovaxId (Idiotype
vaccine therapy) for follicular non-Hodgkin lymphoma, and GV1001 for advanced pancreatic cancer.
In some instances, some antibodies, called idiotype
antibodies, act as antigens, triggering an immune response similar to that described above.
Phase II trial of idiotype
vaccination in previously treated patients with indolent non-Hodgkin's lymphoma resulting in durable clinical responses.
In an accompanying editorial, "Idiotype
vaccination in follicular lymphoma: knocking on the doorway to a cure," Dr.
The topics include the purification of primary malignant B-cells and immunoblot analysis of Bcl-2 family proteins, idiotype
gene rescue in follicular lymphoma, and antibody techniques used to study anaplastic lymphoma kinase-positive ALCL.
But now compare the idiotype
represented by hypothetical Genotype A.