It has a complete immune system with a diverse antibody repertoire and generates antibodies with human idiotypes
as effectively as wild-type animals make rat antibodies.
Weiss, "Processing and presentation of idiotypes
to MHC-restricted T cells," International Reviews of Immunology, vol.
Traditional local genotypes appear to make idiotypes
in ours conditions culture .
This approach is based on the immune network theory of Jerne (1974), who proposed that the immune system is a network of interacting idiotypes
that is involved in the regulation of immune responses.
Specific antibodies have repeated (cross-reacting, or general) idiotypes
and so-called private idiotypes
An ingenious series of recombination events lead to the shuffling of the sequence of the V domains and ensure that the immune system can employ a vast repertoire (estimated at [10.sup.7] different so-called idiotypes
) of Igs, with each B lymphocyte displaying only one particular variant that matches a single particular antigenic epitope.
are unique amino acid sequences in the variable regions of antibodies.
located on light and heavy chains of human myeloma proteins characterized by monoclonal antibodies.
This test involves separation of EPO idiotypes
by isoelectric focussing, immunoblotting, and detection of IgG labeled with streptiverdin-peroxidase.
By knowing the landscape of the AMMI parameter space, with the locations of current winners and the regions for potential and even universal new winners, desirable idiotypes
can be defined.