In order to simulate immune networks, a bio-inspired network model known as Idiotypic
network theory (INT) is used.
This result suggested that P3 mAb is able to activate an idiotypic
cascade that involves B and T cells (B-T idiotypic
Previously, the TAAs presented by MHC-I molecules were categorized into different classes based on various molecular criteria such as whether or not they are: overexpressed or exclusively expressed by the cancer cells, encoded by tumorigenic transforming viruses, commonly expressed in fetal tissues and in cancer cells, commonly expressed by cancer cells and adult reproductive tissues such as testis and placenta, cancer histotype and differentiation lineage specific, or idiotypic
Structural diversity of antigen binding sites of antibodies is proved by their idiotypic
Finotti, "Characterization of immune complexes of idiotypic
catalytic and anti-idiotypic inhibitory antibodies in plasma of type 1 diabetic subjects," Molecular Immunology, vol.
Colley, "Antibodies to Trypanosoma cruzi express idiotypic
patterns that can differentiate between patients with asymptomatic or severe Chagas' disease," Journal of Immunology, vol.
immune network: many researchers utilize the equation generated by Farmer et al.
The mechanism of action of IVIg is not completely understood, but may be attributed to interaction or modulation with multiple immune pathways, such as synthesis and release of cytokines and cytokine antagonists, neutralization of circulating autoantibodies by idiotypic
antibodies in IVIg, functional blockade of Fc recep-tors on splenic macrophages, inhibition of complement-induced damage, and blockade of Fas receptors by anti-Fas antibodies present in IVIg (14), (15).
complementarity and antigen-bridging interactions in the anti-lysozyme response.
Heterophile antibody binding to the variable region of the assay antibody (idiotypic
interaction) is less common (5).