imidazole


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im·id·az·ole

 (ĭm′ĭ-dăz′ōl′)
n.
1. An organic crystalline base, C3H4N2, that is an inhibitor of histamine.
2. Any of various derivatives of this compound, which often have antifungal, anthelmintic, or antibiotic properties.

imidazole

(ˌɪmɪdˈæzəʊl; -ɪdəˈzəʊl)
n
1. (Elements & Compounds) Also called: glyoxaline or iminazole a white crystalline basic heterocyclic compound; 1,3-diazole. Formula: C3H4N2
2. (Elements & Compounds) any substituted derivative of this compound
[C19: from imide + azole]

im•id•az•ole

(ˌɪm ɪdˈæz oʊl, -ɪd əˈzoʊl)

n.
a colorless, crystalline, water-soluble, heterocyclic compound, C3H4N2, used chiefly in organic synthesis.
[1890–95; imide + azole]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.imidazole - an organic base C3H4N2; a histamine inhibitor
alkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"
Translations
imidazole
References in periodicals archive ?
[58.] Hardy E, Pupo E, Castellanos-Serra L, Reyes J, Fernandez-Patron C (1997) Sensitive reverse staining of bacterial lipopolysaccharides on polyacrylamide gels by using zinc and imidazole salts.
Imidazole Dipeptides: Chemistry, Analysis, Function and Effects
The resin was pre-equilibrated with 10 volumes of 20 mmol l-1 Tris-HCl pH 8.5, followed by 10 volumes of a solution containing 50 mmol [1.sup.-1] Tris-HCl pH 8.5, 0.3 mol l_l NaCl, and 10 mmol [1.sup.-1] imidazole. After the filtered supernatant was loaded, the column was washed with 50 ml of a solution containing 50 mmol [1.sup.-1] Tris-HCl pH 8.5, 0.3 mol [1.sup.-1] NaCl, and 20 mmol [1.sup.-1] imidazole until the OD280 (wavelength used to measure protein concentration, with absorbance at 280 nm) of the washing solution approached zero.
Pariser discussed is luliconazole (Luzu), a prescription topical imidazole that is available as a 1% cream.
Etomidate is the only imidazole among general anesthesia inducing drugs and has the most favorable therapeutic effect following single bolus administration.
We used the integral area belonging to the protons adjacent to the sulfonate groups and the integral area of the protons next to the carbon of the imidazole moiety degrees of disulfonation obtained from [sup.1]H NMR:
Histamine + [O.sub.2] + [H.sub.2]0 [??](DAO) [??] Imidazole acetaldehyde +N[H.sub.3] + [H.sub.2][0.sub.2]
One of the more promising alternatives is imidazole and its derivatives.
Imidazole an alkaloid from plant secondary metabolites, is an important component of antifungal, anti protozoal, anti helminthic and anti cancer medications.
These preparations belong to the Imidazole group and are fungicidal, rupturing the cell membrane and killing the cell; they are not generally well absorbed as a systemic treatment.
* MICONAZOLE NITRATE- An imidazole antifungal agent, commonly applied topically to the skin or to mucous membranes to cure fungal infections, and a skin conditions.
Wheatish light brown crystals, Yield (2.2 g, 85%), m.p 200-204[degrees]C, IR (KBr, [v.sub.max] in [cm.sup.-1]): 3435 (-NH), 2922 (=C-H), 1683 (C=N), 1620 (C=C), [sup.1]H NMR (DMSO-[d.sub.6], 400 MHz) [delta] ppm: 2.5 (s, 2H, -C[H.sub.2]), 72-74 (d, 1H, -C=CH, [J.sub.H-H] = 16.4 Hz), 75-73 (m, 4 aryl, 3 phenyl protons), 7.8-8.0 (d, 1H, -CH=C, [J.sub.H-H] = 16.4 Hz), 10.0 (s, 1H, -NH of benzimidazole), [sup.13]C NMR (DMSO-[d.sub.6], 100 MHz) [delta] ppm: 102.29, 108.54, 109, 122, 124, 128, 130, 132, 134, 138, 148, 152 (1 dioxymethylene carbon, 6 aryl carbons, 6 phenylic carbons, 2 vinylic carbons and 1 imidazole quaternary carbon), MS (m/z): 265.10 ([M.sup.+*]), Anal.