The affected drugs include: Azithromycin, Donepezil, Haloperidol, Imipramine
HCl, Isosorbide Dinitrate, Naratriptan, Ondansetron, Perphenazine, and Risperidone.
* Group B - drug 1 was given imipramine
of 10 mg/kg (i.p.).
; pentylenetetrazol; caffeine; sodium pentobarbitone; Tween 80 (Sigma-Aldrich Inc., St.
Subsequently first citalopram (20 mg/day) and then imipramine
(plasma level 251 ng/ml, sum of imipramine
and desmethylimipramine) were added.
Antidepressant >180-240 >500 ng/mL
Clinical observations on iproniazid, a tuberculostatic, and imipramine
, which was designed as a neuroleptic, showed that these medications reduce depressive symptoms .
The researchers looked at amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine
, mirtazapine, nefazodone, nortriptyline, paroxetine, sertraline, and venlafaxine (Lancet.
In addition to venlafaxine, the researchers looked at amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, fluoxetine, imipramine
, mirtazapine, nefazodone, nortriptyline, paroxetine, and sertraline (Lancet.
Thence, an additional objective of this work is reporting the effect of antidepressant drug imipramine
on the expression of subunits [alpha] (G[alpha]) of G proteins.
Patient was prescribed Tab Imipramine
25 mg 1 tablet HS for one week, which was increased to 50mg HS in the second week.
The terms searched were "sertraline", "serotonin reuptake inhibitor", "SSRI", "antidepressants", "hyperpigmentation", "pigmentation", and it found case reports of antidepressant associated hyperpigmentation with citalopram (2), mirtazapine (3) and imipramine
. (4, 5, 6, 7) It is interesting to note that in some of the case reports the antidepressants were replaced by sertraline after development of hyperpigmentation, but there was no record as to whether the lesion resolved.
In the National Institute of Mental Health Treatment of Depression Collaborative Research Project (TDCRP), (20) patients in the acute phase of depression were assigned to 16 weeks of CBT, pharmacotherapy (imipramine
) and clinical management (CM), or placebo plus CM.