immunosuppressor


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Noun1.immunosuppressor - a drug that lowers the body's normal immune response
medicament, medication, medicinal drug, medicine - (medicine) something that treats or prevents or alleviates the symptoms of disease
mercaptopurine, Purinethol - a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia
amethopterin, methotrexate, methotrexate sodium - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
References in periodicals archive ?
Researchers had observed that triple-negative breast cancer (TNBC) patients who had higher numbers of a type of immune cell called myeloid-derived immunosuppressor cells (MDSCs) in their bloodstream had poorer outcomes.
Cyclophosphamide (CP), as an alkylating mediator for chemotherapy and immunosuppressor, often has deleterious side effects, especially hepatotoxicity (1).
On the other hand, TGF-[beta] facilitates the EMT induction and increases the levels of mitogenic growth factors leading to immunosuppressor and pro-angiogenic effects to occur [15, 16, 23].
In addition, long-term adverse effects and the financial burden of immunosuppressor (IS) agents have resulted in a trend towards finding practical ways to replace these drugs with tolerance induction methods and to improve graft survival with molecular manipulation techniques.
Considering the lower immunogenicity of the liver, we designed a study to evaluate the safety and efficacy of an immunosuppressor regimen plus induction therapy with low-dose ATG in preserving renal function and preventing liver rejection in LT recipients with pretransplant renal dysfunction.
The present article reports the successful management of a case treated with a combination of steroid injection followed by a topical immunosuppressor.
One such target is transforming growth factor-beta (TGF-[beta]), a potent immunosuppressor that has a negative impact on surrounding NK cells in the tumor microenvironment.
As an immunomodulator, sambiloto can be used as immunostimulatoryagent that boost the immune response when the immunity is reduced, and can also be an immunosuppressor i.e., lowering immune response when the immune system increases beyond normal body conditions.
The Cyclophilin A is a receptor for immunosuppressor agent cyclosporin A.
[4] Administration of immunostimulators as in the case of AIDS and use of immunosuppressor in cases of an exaggerated response of an immune system is appreciating to reconstitute the normal immune system and increase the longevity of life.
These factors contribute in a cumulative way to the creation of the proinflammatory and immunosuppressor microenvironment that favors tumor proliferation [27] The IL-6 and the IL-10 have received major attention owing to their correlation to poor prognosis and inadequate response to treatment [12].