Researchers had observed that triple-negative breast cancer (TNBC) patients who had higher numbers of a type of immune cell called myeloid-derived immunosuppressor
cells (MDSCs) in their bloodstream had poorer outcomes.
Cyclophosphamide (CP), as an alkylating mediator for chemotherapy and immunosuppressor
, often has deleterious side effects, especially hepatotoxicity (1).
On the other hand, TGF-[beta] facilitates the EMT induction and increases the levels of mitogenic growth factors leading to immunosuppressor
and pro-angiogenic effects to occur [15, 16, 23].
In addition, long-term adverse effects and the financial burden of immunosuppressor
(IS) agents have resulted in a trend towards finding practical ways to replace these drugs with tolerance induction methods and to improve graft survival with molecular manipulation techniques.
Considering the lower immunogenicity of the liver, we designed a study to evaluate the safety and efficacy of an immunosuppressor
regimen plus induction therapy with low-dose ATG in preserving renal function and preventing liver rejection in LT recipients with pretransplant renal dysfunction.
The present article reports the successful management of a case treated with a combination of steroid injection followed by a topical immunosuppressor
One such target is transforming growth factor-beta (TGF-[beta]), a potent immunosuppressor
that has a negative impact on surrounding NK cells in the tumor microenvironment.
strategies in the treatment of murine lupus nephritis.
As an immunomodulator, sambiloto can be used as immunostimulatoryagent that boost the immune response when the immunity is reduced, and can also be an immunosuppressor
i.e., lowering immune response when the immune system increases beyond normal body conditions.
The Cyclophilin A is a receptor for immunosuppressor
agent cyclosporin A.
 Administration of immunostimulators as in the case of AIDS and use of immunosuppressor
in cases of an exaggerated response of an immune system is appreciating to reconstitute the normal immune system and increase the longevity of life.
These factors contribute in a cumulative way to the creation of the proinflammatory and immunosuppressor
microenvironment that favors tumor proliferation  The IL-6 and the IL-10 have received major attention owing to their correlation to poor prognosis and inadequate response to treatment .