GlaxoSmithKline plc today announced its decision to stop the MAGRIT trial, a Phase III trial of its MAGE-A3 cancer immunotherapeutic
in non-small cell lung cancer (NSCLC) patients, after establishing that it will not be possible to identify a sub-population of gene-signature positive NSCLC patients that may benefit from the treatment.
They address new principles of immune suppression in cancer and recent thinking in how immunotherapeutic
and chemotherapeutic agents might be combined to defeat mechanisms of tumoral immune suppression and reprogram the inflammatory microenvironment of tumor cells to enhance long-term outcomes.
By utilizing an individual's disease antigens to create a personalized immunotherapeutic
, the broadest possible immune response can be realized to maximize anti-disease activity, and these so-called immunotherapeutics
have the potential as a multi-billion dollar market.
An improved Pythium insidiosum-vaccine formulation with enhanced immunotherapeutic
properties in horses and dogs with pythiosis.
The primary study objective is to evaluate patient-specific anti-viral response to the AGS-004 immunotherapeutic
following four doses over four weeks.
MAGRIT, a randomised, double-blind, placebo-controlled trial, is evaluating the efficacy and safety of the MAGE-A3 cancer immunotherapeutic
in Stage IB, II and IIIA completely resected NSCLC patients whose tumours expressed the MAGE-A3 gene.
The license grants Transgene exclusive access to Virax's Co-X-Gene(TM) technology patents for use in two of Transgene's immunotherapeutic
products, TG4010 (MVA-MUC1-IL2) and TG4001 (MVA-HPV-IL2).
Bonfiglio's specific leadership experience in immunotherapeutic
development will be a tremendous asset to Argos as our pipeline of RNA-loaded dendritic cell based immunotherapies advances," said Hubert Birner, Ph.
Dynavax's pipeline includes: TOLAMBA(TM), a ragweed allergy immunotherapeutic
, that has completed a large-scale Phase 2/3 clinical trial, and is in a supportive clinical trial in ragweed allergic children; HEPLISAV(TM), a hepatitis B vaccine that is currently in a pivotal Phase 3 clinical trial; a cancer therapy currently in a Phase 2 clinical trial; and an asthma immunotherapeutic
that has shown preliminary safety and pharmacologic activity in a Phase 2a clinical trial.
In addition to its lead anti-IgE immunotherapeutic
, Resistentia has initiated pre-clinical development of an immunotherapeutic
against complement factor C5a for the treatment of rheumatoid arthritis and other autoimmune diseases.
Hy's research has formed the basis for the development of several novel immunotherapeutic
agents for a variety of different cancers," said Garo H.
15 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation announced that safety and efficacy data from the company's Phase 2/3 clinical trial of TOLAMBA(TM), its ISS-based ragweed allergy immunotherapeutic
, will be presented in an oral abstract session at the Annual Meeting of the American Association of Allergy, Asthma and Immunology (AAAAI), Saturday, March 4, 2006, in Miami, Florida.