indinavir


Also found in: Thesaurus, Medical, Legal, Encyclopedia, Wikipedia.
Related to indinavir: nelfinavir, saquinavir

in·din·a·vir

 (ĭn-dĭn′ə-vîr)
n.
A protease-inhibiting drug given in the form of its sulfate, used usually in combination with other drugs to suppress the replication of HIV.

[Alteration of inde(ne) + -navir, protease inhibitor suffix (from saquinavir).]

indinavir

(ɪnˈdɪnəˌvɪə)
n
(Pharmacology) pharmacol a protease inhibitor which acts as an antiretroviral and is used to treat AIDS
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.indinavir - a protease inhibitor (trade name Crixivan) used for treating HIV
protease inhibitor, PI - an antiviral drug used against HIV; interrupts HIV replication by binding and blocking HIV protease; often used in combination with other drugs
Translations

indinavir

n indinavir m
References in periodicals archive ?
There is evidence of clinically important drug-drug interactions between cannabis or cannabinoids and the following medications: chlorpromazine, clobazam, clozapine, CNS depressants (e.g., barbiturates, benzodiazepines), disulfiram, hexobarbital, hydrocortisone, ketoconazole, MAO inhibitors, phenytoin, protease inhibitors (indinavir, nelfinavir), theophylline, tricyclic antidepressants and warfarin.
(47) Nephrotoxicity due to protease inhibitors (PIs), mainly indinavir and atazanavir, is related to the formation of urolithiasis and intratubular precipitation, obstructive nephropathy, and acute or chronic interstitial nephritis.
A study published in the journal BMJ Open Diabetes Research and Care identifies the specific drugs as stavudine or first-generation ARVs including nelfinavir or indinavir.
Indinavir (50 [micro]mol/l) [17, 18] is a GLUT-4 antagonist and decreased the uptake of 2-NBDG to 0.5907 [+ or -] 0.0649.
Ingrown toenail and paronychia have been reported secondary to drugs, such as indinavir and indinavir / ritonavir combination.3,4 Excess nail fold granulation tissue and ingrown toenail have also been reported with retinoids, docetaxel, cyclosporine and oral antifungal treatment.5-8
Indinavir is the drug belongs to class of PIs which suppress HIV infection, increases CD4 lymphocyte count, reduced disease progress.
1 h before administration of tacrolimus), group 3 (pretreated with indinavir 10 mg/kg, i.v.
Due to toxicity and availability of safer alternative drugs at our site, stavudine and indinavir were discontinued from use in mid2011.
[28] The hepatotoxicity of this drug class varies with the specific drug, 30% of patient who are treatment with ritonavir show toxicity, but only 6-7% of those are initiated therapy with saquinavir, nelfinavir, or indinavir experienced severe hepatotoxicity.
Se evaluaron un total de 13418 compuestos obtenidos de la libreria PubChem con estructuras similares a A70 (1407), Pepstatin A (7280), Amprenavir (589), Indinavir (1519), Ritonavir (1623) y Saquinavir (1000).
Calcium and non calcium calculi (Struvite, uric acid, cystine, xanthine, indinavir and others).
The company offers protease inhibitors such as ritonavir, darunavir, saquinavir, amprenavir, lopinavir, atazanavir, indinavir and tipranavir.