indirubin


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indirubin

(ˌɪndɪˈruːbɪn)
n
(Pharmacology) pharmacol an isomer of indigotin which may be naturally extracted from the Indigo plant of China, and effective in the treatment of leukaemia
References in periodicals archive ?
Beta-sitosterol (MOL000358) exhibits the largest number of target connections (18), followed by Stigmasterol (MOL000449) with 15 potential targets and Acacetin (MOL001689), Tryptantherin (MOL001808) and Indirubin (MOL002309) with 13 potential targets.
The pathogenesis begins with the metabolism of tryptophan to indole, which is absorbed and detoxified to indoxyl sulfate (liver), and finally excreted by bacteria with sulfatase and/or phosphatase that metabolize indoxyl to indirubin (red) and indigo (blue) (3).
[1] This condition is characterized by purple discoloration of urine in the urine bag because of the presence of the pigments, indigo and indirubin. It is usually seen in chronically catheterized, constipated, bedridden elderly women.
Characterization of a forest soil metagenome clone that confers indirubin and indigo production on Escherichia coli.
For example the bis-indole alkaloid indirubin occasionally present in human urine was amongst the initial cyclin-dependent kinase inhibitor 7].
Indoxyl sulfate is further reduced to indigo or indirubin via an oxidation pathway mitigated by bacterial enzymes.
Indoxyl sulfate was excreted into the urine and metabolized by bacteria to produce indigo (blue) and indirubin (red, [Figure 2]).{Figure 2}
Endicott et al., "Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases," Nature Cell Biology, vol.
[2] reported the cells of Escherichia coli expressing biphenyl dioxygenase and biphenyl-2,3-dihydrodiol-2,3-dehydrogenase of Dyella ginsengisoli LA-4 transformed indole to indigo, indirubin, and isatin.
The indoxyl turns into indigo which is blue in color and indirubin which is red in color.
This phenomenon is due to the presence of indigo and indirubin in the collected urine.