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 (ĭn′dō-lăm′ēn, ĭn′dō-lə-mēn′)
Any of various naturally occurring analogs of indole, such as serotonin, containing an amine group.
References in periodicals archive ?
Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlamydia trachomatis persistence in human epithelial cells.
O'Connor JC, Lawson MA, Andre C, et al Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice.
According to a new study published in the Nature Journal Scientific Reports, high levels of this enzyme, indoleamine 2,3 dioxygenase (IDO) at diagnosis also identifies those who might benefit most by taking an IDO inhibitor along with their standard therapy.
MSCs regulate effector functions of adaptive and innate immune cells through the release of soluble factors such as prostaglandin E2, nitric oxide, and indoleamine 2,3-dioxygenase (IDO) (8).
Previous studies have demonstrated that the activity of indoleamine 2, 3-dioxygenase (IDO) in patients with lepromatous type leprosy is higher than those with tuberculoid type leprosy.
Indoleamine 2,3-dioxygenase 1 is a key immunosuppressive enzyme that modulates the anti-tumor immune response by promoting regulatory T cell generation and blocking effector T cell activation, thereby facilitating tumor growth by allowing cancer cells to avoid immune surveillance.
Additionally, under the influence of chronic inflammation or immune activity, serotonin levels drop because inflammation activates the enzyme indoleamine 2,3-dioxidase (IDO).
Abstract: Tryptophan 2,3-dioxygenase (TDO) exist only in liver while indoleamine 2, 3-dioxygenase (IDO) exists ubiquitously in the body, these are the most rate-limiting enzymes of kynurenine pathway (KP).
This triple combination study is assessing the safety and effectiveness of the company's DPX-Survivac, along with Incyte's investigational oral indoleamine 2,3-dioxygenase 1 (IDO1) enzyme inhibitor, epacadostat, and low-dose cyclophosphamide in patients with recurrent ovarian cancer who have measurable disease.
Although the AhR has an anti-inflammatory role as a mediator of the expression of the immune regulatory enzyme indoleamine 2,3,-dioxygenase (Vogel et al.
Melatonin is an indoleamine derived from the serotonin secreted during darkness that acts as a natural inhibitor of the aromatases (Hafez and Hafez, 2003).