indomethacin


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in·do·meth·a·cin

 (ĭn′dō-mĕth′ə-sĭn)
n.
A nonsteroidal anti-inflammatory, antipyretic, and analgesic drug, C19H16ClNO4, used especially in the treatment of some forms of arthritis. Also called indometacin.

indomethacin

(ˌɪndəʊˈmɛθəsɪn) or

indometacin

n
(Pharmacology) a drug administered orally to relieve pain, fever, and inflammation, esp in rheumatoid arthritis. Formula: C19H16ClNO4
[C20: from indole + meth- + acetic acid + -in]

in•do•meth•a•cin

(ˌɪn doʊˈmɛθ ə sɪn)
n.
a substance, C19H16ClNO4, with anti-inflammatory, antipyretic, and analgesic properties.
[1963; indo (le) + meth (yl) + ac (etic) + -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.indomethacin - a nonsteroidal anti-inflammatory drug (trade name Indocin)
nonsteroidal anti-inflammatory, nonsteroidal anti-inflammatory drug, NSAID - an anti-inflammatory drug that does not contain steroids; "NSAIDs inhibit the activity of both Cox-1 and Cox-2 enzymes"
acetic acid, ethanoic acid - a colorless pungent liquid widely used in manufacturing plastics and pharmaceuticals
Translations
indometacin

indomethacin

n indometacina
References in periodicals archive ?
Indomethacin (INDO) was used as a positive control and it decreased the edema volume by 57% (Figure 2).
Baby was then started on indomethacin (2mg/kg/day).
Table 1 shows the effect of lisinopril and Indomethacin drug in carrageenan induced paw oedema using vernier callipers.
In the tetrandrine and indomethacin groups, cartilage lesions associated with OA were clearly seen, but the severity was milder than in the control group.
We selected articles adopting a highly sensitive search strategy in order to identify reports of RCTs, with a combination of medical subject headings and text words that included the following: (i) cholangiopancreatography, endoscopic retrograde; (ii) pancreatitis; and (iii) anti-inflammatory agents, nonsteroidal or indomethacin or ibuprofen or diclofenac.
First group was control (CTL), second was given indomethacin 3 mg/kg (INDO) while groups AVL, AVM, and AVH were given 200, 400 and 800 mg/kg doses of Aloe vera gel extract orally for a period of 28 days.
(v) Group 5 (NTG + ID): injected with NTG (1 mg/100 g body weight), 1ml i.p + Indomethacin injected i.p., 0.5 mg/100 g body weight i.p., 30 min previous to the formalin test [24]
Animals of either sex were randomly assigned to five groups (n = 10) for intragastric administration: vehicle (0.5% Tween-80), Indo (indomethacin, 10mg/kg, positive drug), PAO (10, 20, and 40mg/kg for PAO-L, PAO-M, PAO-H, resp.).
The control group received vehicle (0.9% NaCl: 5% Cremophor; p.o.) and experimental groups received usnic acid (UA, 2000, 300, and 50 mg/kg; p.o.), poly-[epsilon]-caprolactone microsphere polymers containing usnic acid (UA-micro, 2000 mg/kg; p.o.), or indomethacin (10 mg/kg; p.o.).
In addition, the odds of hospitalization for heart failure doubled for diclofenac, etoricoxib, indomethacin, piroxicam, and rofecoxib when dosed at two or more daily dose equivalents, the researchers noted.