innate immune system


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innate immune system

n.
The component of the immune system that is relatively nonspecific and immediate and includes mucous secretions, complement proteins, and certain white blood cells, especially neutrophils, macrophages, and dendritic cells. It is one of two main components of the vertebrate immune system, along with the adaptive immune system.
References in periodicals archive ?
As neuropathological changes, such as the deposition of beta-Amyloid plaques, accumulate, the brain's innate immune system is activated.
The topics include the innate immune system: always on guard, the microbiota of the human body: microbiomes and beyond, identifying virulence factors: molecular approaches for host factors, antimicrobial compounds and their targets, and the changing roles of microbiologists in an age of bioterrorism and emerging diseases.
Their investigation revealed that the placenta preferentially sifts out and delivers to the infant antibodies that activate natural killer (NK) cells, key elements of the innate immune system. While several important immune cells are too immature in newborns to provide effective protection, NK cells are among the most abundant and functional immune cells during the first days of life.
Natural killer cells are part of the innate immune system. Their role is to detect virus-infected cells and destroy them.
SYNB1891 is a non-pathogenic strain of E.coli that has been engineered to express a STING (STimulator of INterferon Genes) agonist and stimulate the innate immune system.
IFM Tre, a subsidiary of IFM Therapeutics, is a biopharmaceutical company developing a suite of small-molecule antagonists targeting inappropriate inflammatory responses of the innate immune system through the NLRP3 pathway, which is believed to underlie a variety of serious diseases.
It modulates the response of the innate immune system in response to various stimuli, including infection, tissue damage and inflammation.
Every day we are exposed to millions of pathogens, through contact, ingestion and the air we breathe1 and the first layer of defense against this assault is the innate immune system. Initially, this defense comprises physical barriers such as epithelial surfaces, cilia and secreted substances including tears and saliva, but these are breached by some pathogens.
The human innate immune system is capable of detecting all pathogens quickly, sensitively and effectively.
It points to a mechanism involving the TLR7 receptor (Toll-like Receptor 7), usually activated in innate immune system cells by pathogen recognition.
"Fast food sensor" in the immune cells "It has only recently been discovered that the innate immune system has a form of memory," explains Prof.
According to the researchers, when a body is under attack from a virus or bacteria, the innate immune system detects them and responds by producing signaling molecules called interferons.