insertional mutagenesis

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Noun1.insertional mutagenesis - (genetics) a mutation caused by the insertion of exogenous DNA into a genome
genetic science, genetics - the branch of biology that studies heredity and variation in organisms
mutagenesis - an event capable of causing a mutation
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Recent technical advances have broadened the available approaches for disrupting gene function in a cell population prior to screening, from chemical and insertional mutagenesis to RNA interference, and, most recently, CRISPR mediated genome editing.
Genetic transformation of Colletotrichum truncatum associated with anthracnose disease of chili by random insertional mutagenesis. Journal of Basic Microbiology, Weinheim, v.
In recent years, a few gene manipulation approaches, such as homologous recombination [5-7], T-DNA insertional mutagenesis [8, 9], and RNA interference [10-12], have been employed to study the pathogenicity-related genes in M.
Furthermore, the approach generates a higher percentage of transformants containing just a single-copy of the integrated T-DNA at random chromosomal sites in the fungal genome allowing for random insertional mutagenesis studies (Mulliuns et al., 2001; Rolland et al., 2003; Tsuji et al., 2003; Leclerque et al., 2004; Li et al., 2005).
Therefore, ATMT can be utilized as an efficient tool for insertional mutagenesis and further investigations into the molecular mechanisms of V.
To try to find the events that conspire to cause acute myeloid leukaemia, the team studied the same mice using a technique called 'insertional mutagenesis', in which tagged DNA is inserted into the mouse genome.