integrin


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in·te·grin

 (ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

integrin

(ɪnˈtɛɡrɪn)
n
a protein that acts as a signal receptor between cells
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Release date- 30082019 - WALTHAM - Morphic Therapeutic (Nasdaq: MORF), a biopharmaceutical company developing a new generation of oral integrin therapies for the treatment of serious chronic diseases, today announced that Praveen Tipirneni, M.D., president and chief executive officer, will present a corporate overview at the Wells Fargo Securities2019 Healthcare Conference on Thursday, September 5, 2019 at 3:05pm ET, in Boston.
Through their partnership, Morphic and Schrodinger have accelerated the discovery and design of potent and selective integrin inhibitors and activators targeting serious chronic diseases, including autoimmune, cardiovascular, and metabolic diseases, fibrosis, and cancer.
(15) It is a humanized monoclonal antibody designed to specifically antagonize the alpha4beta7 integrin, inhibiting the binding of alpha4beta7 integrin to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1), but not vascular cell adhesion molecule 1 (VCAM-1).
Protagonist Therapeutics announced results from the initial single ascending dose part of the Phase 1 study of PN-943, an oral, gut-restricted alpha-4-beta-7 integrin specific antagonist in development for the potential treatment of inflammatory bowel disease.
Morphic Therapeutic, a biotechnology company developing oral integrin therapies, has signed a research and development collaboration with United States-based Janssen Biotech, it was reported on Friday.
The researchers found that specialised white blood cells called regulatory T cells from Crohn's patients produced less of a gut-specific protein called integrin EAA4EAA7 than regulatory T cells from healthy people.
Global Banking News-October 19, 2018-AbbVie & Morphic partnership to develop oral integrin drugs targeting fibrotic diseases
(EA Pharma) have revealed a mechanism in which an analogue (ER-464195-01) of Eisai's in-house discovered E6007 inhibits integrin activation by dissociating interaction between calreticulin (CRT) and integrin alpha 4 (ITGA4), suppressing adhesion and infiltration of leukocytes overall.
Later, at the Trochophore stage (24 hpf), [beta]1-like integrin was detectable in the developing stomach area.
(3) Moreover, some studies showed that the adhesion capacity of highly metastatic cells could be reduced by inhibiting integrin expression or modifies the process that leads metastatic cells to anoikis, which is programmed cell death that is induced upon cell detachment from ECM.