Clinically, CKG presents as a self-limiting illness characterized by acute onset of high grade fever accompanied by severe arthralgia, myalgia, headache and various mucocutaneous manifestations.1 The name is derived from the Makonde language of Tanzania meaning "that which bends up" in reference to the contorted posture because of severe joint pain in this illness.2 The first outbreak of CKG was documented in Makonde, United Republic of Tanzania in 1952.2,3 The disease has been reported mainly from Africa and different Asian countries cyclically, with an interepidemic
interval of several years to decades.4 Although there is evidence of persistence of the virus at a low level in the community; explosive outbreaks after periods of long quiescence is the usual epidemiologic pattern.5
Recent entomological studies have confirmed this situation in particular for RVF where there has been more and more evidence of disease interepidemic
activities [7,1720], underlined by sporadic outbreaks on livestock at low levels.
The authors emphasized how this population could contribute to DENV-persistent circulation during interepidemic
periods by efficiently infecting mosquito vectors.
Figures 9(a), 9(b), 10(a), and 10(b) showthe interepidemic
nature of some selected parameters in the SC7.RS model presented above.
albopictus female mosquitoes to their eggs that may have served as an interepidemic
reservoir between outbreaks in successive years in Pakistan.
Extinction and Rapid Emergence of Strains of Dengue 3 Virus during an Interepidemic
Rocha et al., "Epidemiology of dengue virus in iquitos, Peru 1999 to 2005: interepidemic
and epidemic patterns of transmission," PLOS Neglected Tropical Diseases, vol.
In Myanmar, the burden of CRS during interepidemic
periods was similar to that seen prior to the introduction of RCV in developed countries .
 However, during 2009-2010, Namibia was one of several countries in southern Africa that experienced measles outbreaks following prolonged interepidemic
During this interepidemic
period, many entomological WNV surveillance pro grams in the region were eliminated or had limited activities due to an additive impact of low WNV activities and global economic hardship.
They found years with higher and lower incidences, that is, epidemic years interspersed by interepidemic
periods (19,20), similar to our results.
This is a prospective observational study in interepidemic
period of pertussis.