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[ClickPress, Tue Feb 26 2019] Recombinant human interferon protein (IFN-y) is a bioactive protein primarily used for cell culture applications in many diagnostic laboratories.
Tanuja Chitnis, M.D., from Massachusetts General Hospital in Boston, and colleagues compared outcomes in patients aged 10 to 17 years with relapsing multiple sclerosis who were randomized to receive fingolimod (107 participants) or interferon beta-1a (108 participants) for up to two years.
The ISDR mutations for nonstructural protein 5A in non-responders have been reported as a possible explanation of HCV interferon resistance.
With respect to interferon therapy, patients with undetectable hepatitis C virus-ribonucleic acid along with normal alanine aminotransferase were considered responders and patients with detectable hepatitis C virus-ribonucleic acid at week 48 were considered as non-responders.
All patients received combination treatment with standard interferon and ribavirin according to Pakistan Society of Gastroenterology (PSG) guidelines 2009 for 24 weeks.
They were divided in to two groups, one who used interferon and the other who did not.
Currently many brands of Interferon are available in Pakistani market which has come from Argentina, Brazil, China, Cuba, India, South Korea etc.
Justice Muhammad Khalid Mehmood Khan passed the orders on a petition filed by Prof Zahid Mehmood and others against alleged impediment on the part of the authorities concerned to production of cheap interferon injection for the treatment of hepatitis-C.
We assessed all articles for the levels of evidence and employed the following keywords or combinations thereof: interferon; pegylated interferon; hepatitis C virus; HCV; cardiovascular complication; heart; coronary artery; cardiomyopathy; pericarditis; myocarditis; retina; retinopathy; nephropathy; pulmonary; lung disease; gastrointestinal; intestinal injury; myopathy; myositis; myopathy; ischemia; thyroiditis; etc.
In contrast, today's standard therapy, consisting of either of the protease inhibitors telaprevir (Incivek) or boceprevir (Victrelis) combined with pegylated interferon and ribavirin, has a 70%-75% cure rate.
The investigators found that treatment with topically applied (oral) interferon daily led to improvement in both the clinical appearance of the lesions as well as pain scores, comparable to anti-inflammatory and immunosuppressive drugs.

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