The study showed that treatment with emapalumab led to rapid neutralisation of interferon gamma
(IFN) and a complete response in all patients who participated in the study.
Apart from oncology, in the immunoregulation area, another of Enzo's research collaborators has shown that SK1-I prevents the induction of Interferon Gamma
, a major inflammatory biomarker, in a well-established Concanavalin A induced animal model of autoimmune hepatitis.
Swedish Orphan Biovitrum AB (Sobi) (STO:SOBI) an international biopharmaceutical company dedicated to rare diseases, and Novimmune SA, a Swiss biotechnology company, announced on Tuesday the approval by the US Food and Drug Administration (FDA) of Gamifant (emapalumab-lzsg), an interferon gamma
(IFN?) blocking antibody, for the treatment of paediatric (newborn and older) and adult patients with primary haemophagocytic lymphohistiocytosis (HLH) with refractory, recurrent or progressive disease or intolerance to conventional HLH therapy.
El Sharkawy added, "We found that patients with the risk genetic variation had lower expression of STAT4 in their liver and immune cells, reducing their immune response against hepatitis B and their production of interferon gamma
, a protein responsible for moderating fibrosis."
Citation: Jaebok Choi et al., Baricitinib-induced blockade of interferon gamma
receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease.
Updated guidelines for using interferon gamma
release assays to detect Mycobacterium tuberculosis infection, United States, 2010.
Role of QuantiFERON-TB gold, interferon gamma
inducible protein-10 and tuberculin skin test in active tuberculosis diagnosis.
In the last decade, Interferon Gamma
Release Assays (IGRAs) have been developed to improve the specificity of TBI detection, and IGRAs directly or indirectly measure the release of interferon-gamma (IFN-[gamma]) by peripheral blood mononuclear cells (PBMCs) upon stimulation by the RD1-encoded Mtb specific antigens, ESAT-6, CFP-10, and TB7.7 (Rv2654c) .
, IL-12, IL-12R and STAT-1 immunodeficiency diseases: disorders of the interface of innate and adaptive immunity.
Each group was divided into five times observations in the 2nd, 4th, 6th, 8th and tenth day towards the adaptive immune response in the form of levels of Interferon Gamma
(IFN[gamma]) using ELISA and the number of T-helper cells ([CD4.sup.+]) by immunohistochemical methods.
Pareek, "Interferon gamma
release assays: principles and practice," Enfermedades Infecciosas Y Microbiologia Clinica, vol.