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Any of a family of cytokines that are released by macrophages and other cells and stimulate the inflammatory response.
References in periodicals archive ?
Johnson et al reported that the presence of elevated Interleukin-1 levels at the habitual site of smokeless tobacco placement suggests that tobacco components exert a localized effect on IL-1 production.
For IHC evaluations fetal lung samples were stained with surfactant proteins A, B, C, and D (Santa Cruz Biotechnology Inc, USA), prosurfactant protein B (Abcam, UK), interleukin-1, interleukin-4, interleukin-6, interleukin-10, tumor necrosis factor (TNF)-alpha, caspase 3, caspase 5, caspase 7, COX-1, COX-2, interferon-alpha, and interferon-beta (Abcam, UK).
Circulating interleukin-1 and tumor necrosis factor in septic shock and experimental endotoxin fever.
Interleukin-1 (IL-1) is a pro-inflammatory cytokine and main mediator of immune responses.
PF-06650833: An interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor under investigation for the treatment of rheumatoid arthritis.
This results in a lethal systemic inflammatory disease with severe skin and bone involvement, termed deficiency of interleukin-1 receptor antagonist (DIRA) [52].
A recent article in the Journal of Periodontology supports the value of Interleukin-1 (IL-1) genetics in amplifying the negative impact of obesity.
She describes the basic aspects of biology and the concept of body messages and their receptors; methodological approaches to scientific inquiry; the history of the identification of members of the interleukin-1 family; the importance of the balance between pro and anti-inflammatory molecules, and the identification of tumor necrosis factor, interleukin-10, chemokines, and annexin A1; cytokine decoys that have been used as pharmacological treatments; the role of interleukin-6 in the liver, as well as CRP (C reactive protein), SAA (serum amyloid A), and hepcidin; and the discovery and biology of leptin and adiponectin in understanding fat.
The first signal is induced when PAMPs stimulate a pattern--recognition receptor and leads to production of the interleukin-1 precursor.
An increasing body of evidence suggests the potential involvement of interleukin-1 (IL-1) in a number of autoinflammatory diseases, including rare systemic inflammatory diseases such as Still's disease (systemic juvenile idiopathic arthritis and adult onset Still's disease), as well as more common autoinflammatory diseases such as acute gout.
It is a protein drug that blocks the biological activity of IL-1a and IL -1b by binding to interleukin-1 type 1 receptor (IL-R 1), expressed in a variety of tissues and organs, and thereby blocking the interleukin-1 (IL-1) signalling.