intermediate filament


Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.

intermediate filament

n.
Any of a group of protein filaments that are a component of the cytoskeleton in animal cells, are composed of a variety of proteins such as lamins and keratins, and provide structural support for the cytoplasm and nucleus. Intermediate filaments are intermediate in diameter between microfilaments and microtubules, the other components of the cytoskeleton.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Intermediate filament proteins, or nanofilament proteins as they are sometimes called, are important stress proteins that in many cell types act as crisis command centers in times of cellular stress and emerge as interesting targets in many diseases.
Intermediate filament aggregation in fibroblasts of giant axonal neuropathy patients is aggravated in non dividing cells and by microtubule destabilization.
Keratin intermediate filament (KRT-IF) is composed of type I and II keratins; a labeled keratin intermediate filament type II (KIFII) gene was introduced into sheep and the wool quality obtained from transgenic sheep was significantly improved, with the wool fiber exhibiting high gloss and significant flexibility [12].
During myoblast development, this protein copolymerizes with nestin and gradually disappears during subsequent differentiation to myotubes, when desmin becomes the prevailing intermediate filament (Cizkova et al.).
Nestin is a class VI intermediate filament protein that, among other neural cells in the developing and adult central nervous system, was thought to be expressed exclusively in uncommitted neural progenitor cells (NPCs) and in endothelial cells [51-54], but it is also expressed in reactive astrocytes, especially after a brain injury [55].
Folpe, "Aberrant intermediate filament and synaptophysin expression is a frequent event in malignant melanoma: an immunohistochemical study of 73 cases," Modern Pathology, vol.
The keratins are intermediate filament proteins and are important for integrity and mechanical stability of epithelial cells with the largest number of keratin genes expressed in skin.
[18] In most adult peripheral nerves, however, [alpha]-internexin is markedly downregulated during the embryonic development to hardly any detectable levels, and its disappearance from the PNS coincides with the appearance of another intermediate filament protein, peripherin.
Desmin intermediate filament by Nova link polymer detection system was used, according to kit instructions.
Interactions of intermediate filament protein synemin with dystrophin and utrophin.
(12) Anti-p53 mouse monoclonal antibody (clone-DO7, Cell Marque, Rocklin, CA, USA) used which reacted with mutant as well as wild form of p53 and Ck20 mouse monoclonal antibody (Clone-Ks20.8, Cell Marque, Rocklin, CA, USA) used and reacted with intermediate filament of cytoplasm and cell membrane.
In this review, we will present the recent findings from our laboratory indicating that signaling mechanisms involved in regulating intermediate filament phosphorylation/dephosphorylation are important targets of [(PhTe).sub.2].

Full browser ?