internucleotide

internucleotide

(ˌɪntəˈnjuːklɪəˌtaɪd)
adj
(Biochemistry) biochem occurring or existing between nucleotides
References in periodicals archive ?
Synthego's modified sgRNA are synthesized with 2'-O-methyl analogs and 3' phosphorothioate internucleotide linkages in the first three nucleotides at both the 5' and 3' end of the RNA molecule.
2 --O--R (SEQ ID NO:1), wherein X is an internucleotide linkage of type o or s, with the proviso that x is an s linkage at least 4 times and at most 9 times, and o means a phosphodiester internucleoside linkage, s means a phosphorothioate internucleoside linkage, R means a C.
Solid-phase synthesis of oligodeoxynucleotides containing phosphoramidite internucleotide linkages and their specific chemical.
The newly issued patent is an extension of previously issued patents (United States Patent 5,652,355, 6,143,881 and 6,346,614) and claims oligonucleotides comprising a deoxyribonucleotide, a 2'-substituted ribonucleotide, and a phosphorothioate or phosphorodithioate internucleotide linkage, where the 2'-substitution is either 2'-O-aryl ribonucleotide or a 2'-O-amino ribonucleotide.