No patient experience complications or intolerability
necessitating therapy withdrawal despite concerns over its potential for inducing bladder spasms or flushing.
Bedaquiline received accelerated approval in the United States in 2012 for the treatment of pulmonary MDR TB as part of an appropriate combination therapy in adult patients with resistance or intolerability
to other treatment regimens.
Among the 65 patients included, 4 patients had a premature (<2 weeks) IGB removal due to intolerability
, 5 patients had an early (<3 months) IGB removal, and 27 patients kept their IGB in place for an acceptable period between 3 and 6 months, while the remaining 29 patients kept the IGB for longer than 6 months (ranging between 6 and 10 months).
A plaintiff must prove the intolerability
of working conditions and the deliberateness of the employer's action.
52 patients were randomized to five cohorts of Apristor (onapristone extended release tablets 10, 20, 30, 40 or 50 mg BID; n=46), or immediate release onapristone 100 mg QD until progressive disease or intolerability
Inadequate response or intolerability
to oral methotrexate: Is it optimal to switch to subcutaneous methotrexate prior to considering therapy with biologies?
"However, recent observations of oral intolerability
at the current dose and formulation, in a subset of patients, in both studies, indicate that more formulation and dose-ranging studies are required, which is challenging for the company based upon our current resources." The company's Board of Directors and its management are in alignment that the company's best path forward to preserve stockholder value is to focus its resources on assessing strategic alternatives, including the potential sale or merger of the company.
The "normal man" can now partake--through reading--of Sade's consciousness "with ease," but at the cost of inhibition, before the intolerability
of this awareness' contents, of any translation of consciousness into action.
Rather than carve out a space away from the depredations of capitalism, as bourgeois individualism sought to do, Miller's method is to mirror these processes, pushing them to the point of intolerability
. With "cool scientific detachment" (144), Miller observes white-collar labor expanding to colonize intimate life so that sex becomes interminable work abstracted from any purpose or end; as he watches two people coupling, for example, he can think only of the printing presses at his job, endlessly spitting out newspapers.
Our washout period used to define IIPEs also possibly was not long enough and the intolerability
or ineffectiveness of previous antipsychotics used by patients may have led to aripiprazole being prescribed.
During the course of the treatment, the patient did not experience any intolerability
relating to nephrotoxicity, which is the dose-limiting toxicity of platinum-based chemotherapy.