Some nuclei contained
intranuclear pseudo-inclusions.
The disease is characterized by its sudden onset, accumulation of jelly like fluid in the pericardial sac, inflammation of liver with overwhelming
intranuclear inclusion bodies and congested kidneys.
Common morphologic features of viral infection include cytomegaly, syncytia formation, and intracytoplasmic and/or
intranuclear inclusions.
Nuclear clearing, grooves, nuclear membrane thickening and
intranuclear inclusions which are features of PTC can be seen in reactive follicular cells of HT too.
Abnormal ocular alignment frequently results from damage to the
intranuclear portion of the gaze system, including: cranial nerves (CN) III (oculomotor), IV (trochlear), and VI (abducens), or the myoneural junction or extraocular muscles they innervate.
Nemaline rods are usually sarcoplasmic but may be
intranuclear in up to 17% of cases.
The IHC study of CD-99 (a cell membrane glycoprotein) and
intranuclear FLI-1 (a DNA-binding transcription factor) is important to diagnose ES.
Intranuclear, mostly eosinophilic inclusion bodies are found in the cells at the periphery of necrotic lesions in the liver and also in the spleen, bone marrow, and intestines to a lesser extent.
Intranuclear pseudoinclusions as a single diagnostic pointer to the likely primary site of origin can be misleading as, in addition to their occurrence in papillary thyroid carcinoma, they are also evident in pulmonary papillary adenocarcinoma, hepatocellular carcinoma, melanoma, meningioma and variants of parenchymal renal cell carcinoma (1,13).
The nuclei are usually round-oval, contains thin nuclear chromatin and occasionally
intranuclear pseudoinclusions.
This can result in the formation of
intranuclear inclusion bodies causing muscle cell pathology.
OPMD is a neuromuscular disease that is caused by mutations in the gene coding for polyA-binding protein nuclear 1, or PABPN1, which can lead to formation of
intranuclear inclusion bodies causing muscle cell pathology.