Finally, its application or injection into blood vessels should be strictly avoided because GTM intravasation
may result in thromboembolism, as discussed in the "safety and adverse effects of GTM in gynecological surgery" section (20).
The activity status of cofilin is directly related to invasion, intravasation
, and metastasis of mammary tumors.
Tumor metastasis is a multistep process that includes the development of new blood vessels, detachment of metastatic cells from the primary tumor, invasion to stroma, intravasation
to the blood and lymphatic vessels and extravasation to the target organ and growth of secondary tumor (26).
Metastasis is the result of a stepwise sequence involving the individual or collective invasion of neoplastic cells locally, their entry into the vascular system (intravasation
) and survival in circulation, the extravasation at distant sites and, finally, the establishment and colonization by disseminated tumor cells in new tissues and organs (Valastyan & Weinberg, 2011; Lambert et al., 2017).
Concerns include the rare theoretical risk of intravasation
with subsequent allergic reaction or fat embolism.
Kupriyanova et al., "Tumor-recruited neutrophils and neutrophil TIMP-free MMP-9 regulate coordinately the levels of tumor angiogenesis and efficiency of malignant cell intravasation
," The American Journal of Pathology, vol.
Cellular migration is a complex process encompassing the disintegration of extracellular matrix, detachment of cells from the basal membrane, migration of cells from the original location, intravasation
into the target tissue, and interaction with the target microenvironments .
There is less likelihood of contrast persisting within the pelvic cavity and therefore of complications such as intravasation
resulting in allergic reactions, anaphylaxis or long-term granuloma formation in the tubes (Johnson, Farquhar, Hadden, Suckling, & Sadler, 2004).
The finding, which is now published online in Science Translational Medicine, found that neoadjuvant chemotherapy can increase a process known as intravasation
, which may increase the chances of cancer cells metastasizing in some breast cancer patients.
We used contrast medium of 1-2 mL (iohexol 300 mg/mL) for both confirmation of the targeted nerve root and any intravasation
of the medium.
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation
and metastasis in colorectal cancer.