His B-type natriuretic peptide level, renal function test results, and echocardiography results were all within the normal range, thus excluding the possibilities of intravascular fluid
overload, renal failure, and impairment of cardiac contractility.
Therefore trans-capillary escape of albumin from intravascular compartment leads to decreased intravascular fluid
volume, increased interstitial fluid volume and impaired lymphatic drainage leading to third space fluid accumulation1.
In 1921, after the New Haven Rialto Theatre Fire, Frank Underhill observed that burn shock was related to intravascular fluid
loss rather than direct toxic effects of injury (Peeters, Vandervelden, Wise & Malbrain, 2015).
Study author Mark Nelson, MD of Virginia Commonwealth University, stated that the surprising results of his study showed the inadequacy of current methods of evaluating blood loss, including the widespread use of hematocrit and hemoglobin: "Contrary to the long-held belief that red blood cells are largely conserved during cardiac surgery they are in fact reduced by 38%." He added, "This data beckons the question of transfusion, should peripheral hematocrit continue to be utilized as a determinant." CEO COMMENTS ON BVA-100: Michael Feldschuh CEO of Daxor stated, "This study highlights the BVA-100's unique ability to illuminate intravascular fluid
derangements that are missed by standard diagnostic tests.
The goals of using a loop diuretic is to reduce intravascular fluid
volume and to rapidly decrease preload venous capillary pressures, thereby reducing cardiogenic pulmonary edema (Wall et al., 1992).
ECF is further divided into intravascular fluid
(also known as plasma) and interstitial fluid.