ion channel


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ion channel

n.
A pathway through a protein molecule or complex in a cell membrane that modulates the electrical potential across the membrane by controlling the passage of small inorganic ions into and out of the cell.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
According to the company, SAN903, which is generated from the company's advanced ion channel platform, is a first-in-class product and, Saniona believes it has the potential to transform the treatment paradigm for severe autoimmune diseases, including Crohn's disease and colitis.
Southan has more than 25 years of experience in ion channel research and development, starting his career at Wyeth Research (UK), followed by postdoctoral studies at Imperial College London.
Summary: TEHRAN (FNA)- Biomedical researchers have captured close-up views of TRPV3, a skin-cell ion channel that plays important roles in sensing temperature, itch, and pain.
For some functional studies, especially the electrophysiological studies, hiPSC-CMs have also important advantages over heterologous expression systems like Xenopus oocytes, human embryonic kidney (HEK) cells, and Chinese hamster ovary (CHO) cells lacking important constituents of cardiac ion channel macromolecular complexes that might be necessary for the normal electrophysiological characteristics.
Abstract: In this paper; the effects of autapse (a kind of self-synapse formed between the axon of the soma of a neuron and its own dendrites) and ion channel blockage on the firing regularity of a biological small-world neuronal network, consists of stochastic Hodgkin-Huxley neurons, are studied.
In recent years, ion channel guiding has been put forward as an innovative focusing method for guiding the electron bunch transport [9, 10].
The pH fluctuations affect many cellular processes, including enzymatic activity, membrane receptors, ion channel flow, and membrane transporters [2, 3].
According to its different targets acting on the organism, the conotoxins can be divided into three categories [3]: (1) acting on voltage-gated ion channels, (2) acting on the ligand-gated ion channel, and (3) acting on other receptors.
Metrion will use commercial Axiogenesis cell products in its optimized ion channel screening, cardiac safety and translational phenotypic assays.
This will be TetraGenetics' fifth program launched with either a large pharmaceutical and/or biotech partner for ion channel drug discovery.
The relevance of mitochondrial ion channel research is observed in numerous studies that have demonstrated its participation in the development of pathological conditions like neurodegenerative [35, 55] and cardiac diseases [51, 56-60].