Drug Original indication AAS Non-steroidal Anti-inflammatory Amitriptiline Antidepressant Auranofin Rheumatoidarthritis Chlorpromazine Anti-psychotic Clofazime Tuberculosis Clomipramine Antidepressant Disulfiram Alcoholism Ebselen Neuroprotector Escitalopram Antidepressant Fluoxetine Antidepressant Ibuprofen Non-steroidalAnti-inflammatory Iproniazid
Antidepressant Loperamide Diarrhoea Sertraline Antidepressant Paroxetine Antidepressant Risperidone Anti-psychotic Simvastatin and Cardiovascular diseases Atorvastatin Thalidomide Anti-nausea Drug New indication AAS MRSA Amitriptiline Staphylococcus spp.
The earliest MAOI, iproniazid
, was a hydrazine derivative and exhibited hepatotoxicity, (13) as did certain other hydrazine MAOIs.
Several classes of antidepressants owe their discovery to chance, from iproniazid
, which was initially used to treat tuberculosis in the 1950s, to the tricyclics of the 1960s, which stemmed from an experimental treatment for schizophrenia and the more recent breakthrough involving the use of ketamine .
This was the case of iproniazid
and imipramine, the first clinically efficient antidepressants that rebutted the strictly psycho-emotional theory, considered as the only mechanism in the determining of depression.
Clinical observations on iproniazid
, a tuberculostatic, and imipramine, which was designed as a neuroleptic, showed that these medications reduce depressive symptoms .
Only the comparison with a rather "historical" MAO-inhibitor, iproniazid
, that exhibited very poor affinity for the enzymes when compared with novel generation of MAO blockers permitted consideration of the MAO inhibition by 10-100 [micro]M resveratrol of relevant interest .
Murdoch, "Lectins, calcium ionophore A23187 and peanut oil as deciduogenic agents in the uterus of pseudopregnant mice: effects of tranylcypromine, indomethacin, iproniazid
and propranolol," Australian Journal of Biological Sciences, vol.
In 1952, doctors noted that patients on the antituberculosis drug iproniazid
Anti-TB drug Reported adverse event Isoniazid (INH) Toxic psychoses developed while under treatment or iproniazid
with isoniazid or iproniazid
in combination with (IPH) other antituberculous drugs Cycloserine Showed some type of neurologic or psychiatric disturbance of varying severity Isoniazid and Peripheral neuropathy is associated with the use ethambutol of isoniazid Isoniazid and The optic neuritis manifests with reduced visual ethambutol field or acuity or color vision Isoniazid The behavioral disorders, changes in the rhythm of sleep, reduced memory, and psychosis have been described for the use of isoniazid.
The urinary excretion of adrenaline and noradrenaline by depressive patients during iproniazid