remains the cause of morbidity and mortality in patients with BT major and thalassaemia intermedia.
The aim of the study was to find out the frequency of gene mutation of HFE in Pakistan in iron overload
These transfusions carry the risk of progressive multi-organ damage due to unavoidable iron overload
. ZYNTEGLO is a one-time gene therapy that addresses the underlying genetic cause of TDT and offers patients 12 years and older who do not have a beta0/beta0 genotype the potential to become transfusion independent, which once achieved is expected to be life-long.
Among the topics are iron chelation for iron overload
in thalassemia, iron oxide nanoparticle formulations for supplementation, building a Trojan horse: siderophore-drug conjugates for treating infectious diseases, copper depletion as a therapeutic strategy in cancer, and chemical and clinical aspects of metal-containing antidotes for poisoning by cyanide.
Although transfusions are life savers for such patients but at the same time lead to iron overload
and expose the patients to many other complications like hypersplenism, chronic hepatitis, human immuno-deficiency virus (HIV), venous thrombosis and osteoporosis6.
Deferasirox Tablets for Oral Suspension are indicated for the treatment of chronic iron overload
due to blood transfusions (transfusional hemosiderosis) in patients 2 years of age and older.
Therefore, monocyte in iron overload
condition requires further attention.
Experts believe that the work, which has involved designing a brand new molecule with potential to be added to sun cream, could benefit those with FriedrichaACAOs Ataxia (FA), as well as those with other disorders characterised by mitochondrial iron overload
, notably Wolfram Syndrome and Parkinson's disease, where UVA rays from the sun may pose particular challenges.
Males and post-menopausal women have no mechanism to excrete excess iron, relying on tightly regulated absorption to prevent iron overload
In collaboration with the Ministry of Health, Oman Novartis brought haematology experts who treat iron overload
patients to Muscat, Oman at the Hormuz Grand Hotel.
To avoid complications, the iron overload
is decreased; phlebotomy is the cornerstone in treatment (6).