is one of the most important derivatives of indole with significant bioactive scaffold, containing double adjacent carbonyls with an indole unit and a y-lactam moiety, which endows isatin
with an amount of interesting synthetic applications .
Cavus, Some molecular properties and reaction mechanism of synthesized isatin
thiosemicarbazone and its zinc(II) and nickel(II) complexes, Int.
) is a versatile moiety and compounds bearing the isatin
chemical scaffold demonstrate diverse pharmacological or biological properties (Patel et al.
The synthetic strategy for the synthesis of imines 8a-g has been described in the Scheme 3, involves reaction of acid hydrazide 1 with thiosemicarbazide to give first on a product it is 1-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-3H-benzo[f]chromen-3-one 7, which is considered as starting material for the synthesis of imines 8a-f and 8g by its reaction with substituted aldehydes or isatin
as shown in Scheme 3.
Quraishi, "Adsorption and inhibitive properties of some new Mannich bases of Isatin
derivatives on corrosion of mild steel in acidic media," Corrosion Science, vol.
(indoline-2,3-dione) is synthetically versatile substrate serving as raw material for drug synthesis that can be modified into various heterocyclic compounds including Indoles and Quinolones .
Fassihi, "QSAR study of isatin
analogues as in vitro anti-cancer agents," European Journal of Medicinal Chemistry, vol.
This plant gathers medicinal importance due to the presence of eugenol, fernesol, nerol, tryptanthrine, indigo, indirubin, isatin
, linoleic acid, [alpha]- and [beta]-amirins, carotenoids, sterols, phenolic compounds, rutin, quercetin, kaempherol, famaricetin, luteolin, saponin, alkaloids, terpenoids, tannins, triterpenoids, anthocyanin, flavonoids, steroids, anthraquinones, citric acid, tartaric acid, couroupitine, and pelargonidin glycosides [6-8].
Wang, "Effect of isatin
on the activities of antioxidase in PD model mice," China Pharmacy, vol.
de Faria et al., "Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin
: a molecular mechanism of protection against TNBSinduced colitis in rats," Chemico-Biological Interactions, vol.
De Faria et al., "Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin
: a molecular mechanism of protection against TNBS-induced colitis in rats," Chemico-Biological Interactions, vol.