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Related to isocarboxazid: Linezolid, Selegiline, tranylcypromine


A monoamine oxidase inhibitor, C12H13N3O2, used as an antidepressant.

[Shortening and rearrangement of isoxazolylcarbonyl, one of its constituents + (hydr)azid(e), one of its constituents; see isoniazid.]


(Recreational Drugs) an antidepressant that is derived from hydrazine. Formula: C12H13N3O2
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.isocarboxazid - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depressionisocarboxazid - a monoamine oxidase inhibitor (trade name Marplan) that is used to treat clinical depression
MAOI, monoamine oxidase inhibitor - any of a group of antidepressant drugs that inhibit the action of monoamine oxidase in the brain and so allow monoamines to accumulate
References in periodicals archive ?
2) The Sequenced Treatment Alternatives to Relieve Depression (STARED) study demonstrated that <50% of MDD patients achieve remission in monotherapy trials of selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, mirtazapine, or bupropion, necessitating consideration of antidepressant combinations, augmentation options, and eventually irreversible, nonselective MAOIs such as phenelzine, tranylcypromine, or isocarboxazid.
Monoamine phenelzine (Nardil); Increase oxidase tranylcypromine (Parnate); norepinephrine, inhibitors isocarboxazid (Marplan) serotonin, and (MAOIs) dopamine.
5 75-225 Serotonin modulators Trazodone 50 75-400 Norepinephrine-serotonin modulator (NaSSA) Mirtazapine 15 15-45 Monoamine oxidase inhibitors (MAOIs) Irreversible, nonselective Phenelzine 15 15-90 Tranylcypromine 10 30-60 Isocarboxazid 20 30-60 Reversible MAOI-A Moclobemide 300 300-600 Melatonergic agonist Agomelatine 25 25-50 * Reprinted with permission from APA Practice Guideline for the Treatment of Patients with Major Depressive Disorder, 3rd ed, [c] 2010).
They include phenelzine (Nardil), isocarboxazid (Marplan) and tranylcypromine (Parnate).
A recent meta-analysis (2) found no benefit over placebo of the ADs paroxetine, fluoxetine, amitriptyline and isocarboxazid - studied specifically in patients with 'minor' depression.
1A] receptor agonist used for anxiety) may interact with monoamine oxidase inhibitors (MAOIs), such as isocarboxazid, phenelzine, and tranylcypromine.
phenelzine, isocarboxazid, tranylcypromine) potentiate brain amine levels by inhibiting the breakdown of brain amines.
The first-generation MAOIs such as phenelzine and isocarboxazid were largely nonselective inhibitors of both subtypes of MAO, MAO (A) and MAO (B).
PHILADELPHIA--The monoamine oxidase inhibitor isocarboxazid may be an effective migraine preventive as well, Dr.