(redirected from isogenic)
Also found in: Medical, Encyclopedia.


Genetically identical or closely related, so as to allow tissue transplant; immunologically compatible: syngeneic grafts; syngeneic mice.

[From Greek sungeneia, kinship : syn-, syn- + genos, family; see genə- in Indo-European roots.]

syn·ge·ne′i·cal·ly adv.


(ˌsɪndʒɪˈniːɪk; ˌsɪndʒɪˈneɪɪk) or


(Genetics) with identical genes
References in periodicals archive ?
All these factors are expected to fuel the growth of isogenic cell lines market in near future.
All patient isolates had identical STRAf genotypes suggesting that they were isogenic (Table 1) (4).
In linkage mapping, bi-parental populations [F2, back cross (BC), doubled haploid (DH), recombinant inbred lines (RILs), near isogenic lines (NILs) etc.] are used for mapping purposes.
Furthermore, it was revealed that these disease-relevant phenotypes were also observed in dopaminergic neurons derived from isogenic PARK2 null iPS cells obtained by genome editing.
If on the other hand they all appear isogenic, you are much more likely to have a single source to identify and resolve.
Therefore, the ideal comparison would be between two lines that only differ in the supposed disease-specific mutation and are otherwise genetically matched (isogenic lines).
The genetic background of the cell-free DNA also should be completely defined and isogenic to the mutant DNA.
An isogenic cybrid was produced (Owti) after we obtained platelets from the wild-type mother of the patient harboring the mutation.