All these factors are expected to fuel the growth of isogenic
cell lines market in near future.
All patient isolates had identical STRAf genotypes suggesting that they were isogenic
(Table 1) (4).
In linkage mapping, bi-parental populations [F2, back cross (BC), doubled haploid (DH), recombinant inbred lines (RILs), near isogenic
lines (NILs) etc.] are used for mapping purposes.
Furthermore, it was revealed that these disease-relevant phenotypes were also observed in dopaminergic neurons derived from isogenic
PARK2 null iPS cells obtained by genome editing.
If on the other hand they all appear isogenic
, you are much more likely to have a single source to identify and resolve.
Therefore, the ideal comparison would be between two lines that only differ in the supposed disease-specific mutation and are otherwise genetically matched (isogenic
The genetic background of the cell-free DNA also should be completely defined and isogenic
to the mutant DNA.
frugiperda larvae was carried out using a completely randomized experimental design, with three treatments (two isogenic
Bt corn genotypes and one non-Bt corn genotype) and 11 replications.
cybrid was produced (Owti) after we obtained platelets from the wild-type mother of the patient harboring the mutation.