ENPNewswire-August 22, 2019--Cerecor Receives Fast Track Designation from FDA for CERC-802 for the Treatment of Mannose-Phosphate Isomerase
Cerecor has three compounds under development for CDGs: CERC-801, D-galactose, to treat Phosphoglucomutase 1 Deficiency; CERC-802, D-mannose, to treat Mannose-Phosphate Isomerase
Deficiency; and CERC-803, L-fucose, to treat Leukocyte Adhesion Deficiency Type II or SLC35C1-CDG.
Purification and properties of prostaglandin H-E isomerase
from the cytosol of human brain: Identification as anionic forms of glutathione S transferase.
Notably, reduced expression of enzymes that were implicated in the detoxification of reactive oxygen species, such as thioredoxin peroxidase 2, glutathione S-transferase P (GST) and protein disulfide isomerase
precursor (PDI), were reported to significantly identify patients with poor prognosis as defined by the 17p abnormality and/or short overall survival.
All samples were also subjected to mitochondrial and nuclear DNA typing by analyzing polymorphisms in the cytochrome oxidase subunit II (COII7) and the glucose-phosphate isomerase
(GPI8) genes, respectively.
Mazmanian's group also discovered that the molecule xylose isomerase
(Xi), a protein that breaks down sugar and is found in L.
Cytochrome P450 family 51, farnesyl diphosphate synthase, aisopentenyl-diphosphate delta isomerase
1 are also reported to play a role in cholesterol synthesis [24-26].
Molecular biology of the 3[beta]-hyd roxysteroid dehydrogenase/[[DELTA].sup.5]-[[DELTA].sup.4] isomerase
tuberculatum venom can be grouped basically into proteins involved in insect metabolism (annexin B9, nucleoside diphosphate kinase; aconitate hydratase; superoxide dismutase; triose phosphate isomerase
; glyceraldehyde-3phosphate dehydrogenase; succinyl-CoA ligase; fructosebisphosphate aldolase; arginine kinase; citrate synthase; enolase; ATP synthase; 4-hydroxybutyrate coenzyme A transferase; medium-chain specific acyl-CoA dehydrogenase, and isocitrate dehydrogenase); transport protein (transferrin); and structural proteins (cyclophilin, actin, and chitinase).
Treatment with isomerase
enzymes, such as glucose isomerase
, provides a highly efficient and cost-saving method for production of HFCS.
Cyclophilin A is a protein exhibiting peptidyl-prolyl cis-trans isomerase
activity because of which it assists in protein folding (3).
This discovery project (NVP022) is based on NeuroVive's core competence in mitochondrial energy regulation and the partner company Isomerase
's innovative chemistry capabilities.