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Related to isoniazid: Pyrazinamide


A crystalline antibacterial compound, C6H7N3O, used in the treatment of tuberculosis.

[isoni(cotinic acid), isomer of nicotinic acid (iso- + nicotinic acid) + (hydr)azid(e), one of its constituents (hydr(o)- + az(o)- + -ide).]


(ˌaɪsəʊˈnaɪəzɪd) or


(Pharmacology) a soluble colourless crystalline compound used to treat tuberculosis. Formula: C6H7N3O
[C20 isoni(cotinic acid hydr)azid(e)]


(ˌaɪ səˈnaɪ ə zɪd)

a water-soluble solid, C6H7N3O, used in the treatment of tuberculosis.
[1950–55; short for isonicotinic acid hydrazide]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.isoniazid - antibacterial drug (trade name Nydrazid) used to treat tuberculosis
antibacterial, antibacterial drug, bactericide - any drug that destroys bacteria or inhibits their growth

isoniazid (INH)

n isoniazida
References in periodicals archive ?
They found that while all three drugs significantly altered the composition of the mice's gut microbiome, but mice treated with isoniazid combined with pyrazinamide showed an increase in susceptibility to Mtb infection.
Each patient received a daily total dose of rifampicin (600 mg), isoniazid (300 mg) pyrazinamide (1600 mg) and ethambutol (1100 mg) for two months (intensive phase), followed by rifampicin (600 mg) plus isoniazid (300 mg) for four months (continuation phase).
The most common medication used was isoniazid (730/752, 97.1%), followed by rifampin (20/752, 2.7%); 2 children whose index patient had MDR TB received ethambutol and pyrazinamide.
Keywords: Drug Metal Complexes, Isoniazid, Scanning Electron Microscopy, X-Ray Diffraction and Cytotoxicity.
Isoniazid was marketed in mid of 1950,s and Rifampicin in 1970,s.
The first regimen comprises 9 months of isoniazid treatment.
tuberculosis from patients who subsequently had a relapse or were cured to determine the MIC values of isoniazid and rifampin that were below the standard resistance breakpoint.
A bactericidal agent used with suicidal intent: isoniazid. Journal of the Child 2014; 14: 78-80.
A large randomized clinical trial of 3HP administered by DOT, which included children aged 2-17 years, demonstrated that 3HP was as well-tolerated and as effective as 9 months of daily isoniazid (9H) for preventing TB (5).
Study participants were randomly assigned to a one-month course of rifapentine and Isoniazid or a nine-month course of Isoniazid.