Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to isoniazid: Pyrazinamide


A crystalline antibacterial compound, C6H7N3O, used in the treatment of tuberculosis.

[isoni(cotinic acid), isomer of nicotinic acid (iso- + nicotinic acid) + (hydr)azid(e), one of its constituents (hydr(o)- + az(o)- + -ide).]


(ˌaɪsəʊˈnaɪəzɪd) or


(Pharmacology) a soluble colourless crystalline compound used to treat tuberculosis. Formula: C6H7N3O
[C20 isoni(cotinic acid hydr)azid(e)]


(ˌaɪ səˈnaɪ ə zɪd)

a water-soluble solid, C6H7N3O, used in the treatment of tuberculosis.
[1950–55; short for isonicotinic acid hydrazide]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.isoniazid - antibacterial drug (trade name Nydrazid) used to treat tuberculosis
antibacterial, antibacterial drug, bactericide - any drug that destroys bacteria or inhibits their growth

isoniazid (INH)

n isoniazida
References in periodicals archive ?
Thus in our new paper, we postulate that vitamin C is stimulating respiration of the Mtb cells in mice, thus enabling the action of isoniazid and rifampicin.
Drug susceptibility of isoniazid and rifampicin was carried out by standard drug proportion method.
tuberculosis resistance to antibiotics were due to mutations of the genes targeted by anti-tuberculosis drugs, such as gene rpoB for rifampin, katG gene for isoniazid, pncA gene for pyrazinamide, and embB gene ethambutol [3,4].
The patient was immediately placed in home isolation and started on the standard four-drug therapy of isoniazid, rifampin, ethambutol, and pyrazinamide, pending confirmation and susceptibility testing.
In particular, isoniazid mono-resistance has been associated with high rates of treatment failure and MDR-TB.
Stock solution of the drugs was prepared based on the potency of the drug in sterile distilled water for streptomycin, isoniazid and ethambutol and in absolute methanol for rifampicin.
5%) did not complete IPT because isoniazid was either not prescribed or out of stock.
Genotype MTBDRplus evaluates the main mutations associated with rifampicin (rpoB gene mutations) and isoniazid (katG e inhA mutations) resistance.
In this descriptive study, out of 98 clinical isolates of Mycobacterium tuberculosis at The Tuberculosis Research Center in the Iranian city of Arak, 64 isolates that had already been determined to be phenotypically resistant or susceptible to isoniazid were analyzed for mutations in the regulatory region of inhA-15 with 2 allele-specific polymerase chain reaction (AS-PCR) and sequence methods.
Multi-drug resistant tuberculosis (MDR-TB) is defined as TB that is resistant at least to isoniazid (INH) and Rifampicin (RMP), the two most powerful first line anti tubercular drugs.
ABSTRACTBackground: Different herbal extracts and drugs had been tried to combat the isoniazid induced hepa- totoxicity; there is no study before using propolis for abating isoniazid induced liver toxicity.