The first grant is in Europe and focused on furthering the company's current artificial intelligence (AI) and Informatics platform at Amyris and the second grant is from National Institutes of Health (NIH) for the development of a novel isoprenoid
Mevalonate is the precursor not only of cholesterol but also of many non-steroidal- isoprenoid
CoQ10 or ubiquinone is a lipid-soluble benzoquinone with a side-chain of 10 isoprenoid
units endogenously synthesized from phenylalanine and mevalonic acid.
The major isoprenoid
alkanes in the analysed samples are pristane (Pr) and phytane (Ph) (Fig.
Early models described "mevalonate shunting" from isoprenoid
Through discovery, product development and trials, BBI developed isoprenoid
compounds ("ISO-Extracts[TM]") derived from desert, mountain and sea plants that are highly effective, economical to use, and have broad application in various formulations for fertilizer, stimulant and pesticides.
The first target molecules are part of the isoprenoid
family (including carotenoids) that may lead to the production of specialty ingredients, such as antioxidants and / or high-added value pigments, representing a market of hundreds of millions of dollars worldwide in applications such as cosmetics, food, feed and health.
In plants, the isopentenyl diphosphate and dimethylallyl pyrophosphate (DMAPP) isoprenoid
precursors can be derived from the mevalonate or metileritritol phosphate.
Eucalyptus species are strong source of isoprenoid
Edenharder and Grunhage (2003) reported that the isoprenoid
flavonoids are cytotoxic at high concentrations.
Some researches show that antibacterial compounds contain major bioactive alkaloids, polyketides, terpenoids, isoprenoid
compounds, quinones, and phenol isolated from marine fungi .
3-Hydroxy-3-methylglutaryl-Coenzyme A synthase(HMGS) is the second enzyme in MVA pathway of isoprenoid
biosynthesis, and catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to yield HMG-CoA.