The TANGO study was conducted to assess whether adults living with HIV-1 who had maintained viral suppression for at least six months on a tenofovir alafenamide fumarate, or TAF,-containing regimen of at least three drugs, were able to maintain similar rates of viral suppression after switching to the 2-drug regimen, or 2DR, of dolutegravir plus lamivudine
in a fixed dose combination, compared to continuing the TAF-containing regimen.
One generic HIV drug, lamivudine
, stood out because of its activity and low side effects.
's efficacy and safety in preventing mother-to-child transmission of hepatitis B: A meta-analysis study
(8-10 ) For lamivudine
, the prevalence of resistance rises rapidly, reaching 80% after five years of monotherapy (11) The pattern of rtL180M/M204V is the most common lamivudine-resistant HBV variant, with a prevalence of 60%.
Patients between 18 and 70 years receiving oral antiviral agents (lamivudine
, entecavir, or tenofovir disproxil fumarate) for a minimum duration of 3 years due to CHB were included.
In 2010, the World Health Organization (WHO) recommended HBV screening before ART initiation, and the use of ART regimens containing tenofovir plus either lamivudine
or emtricitabine for HIV/ HBV coinfection.
Two regimen were there based on Tenofovir:Tenofovir, Lamivudine
and Nevirapine Regimen and Tenofovir, Lamivudine
and Efavirenz Regimen.
(GlaxoSmithKline, Brentford, UK), a US Food and Drug Administration-approved anti-HIV drug, has been suggested as a possible antiviral agent against Ebola virus (EBOV).
(4 mg/kg/day) was given to 29 of the patients who were given treatment, interferon-[alpha] (IFN-[alpha]) (6 MU/[m.sup.2], three days a week) was given to 3 patients at the same dose and both IFN-[alpha] and lamivudine
were given to 4 patients.
and telbivudine are prone to develop resistance rapidly.
Group A received a non-nucleoside reverse transcriptase inhibitor (NNRTI), lamivudine
, and abacavir.