Conducting appropriate extractable and leachable
studies for inhaler products, with the potential complexity of the polymer materials in mind, requires suitable, validated and sensitive analytical methods shares Dr Hauk.
The addition of leachables
to a pharmaceutical product stream has several potential negative effects, but the one most relevant to the use of single-use solutions is when the leachable
is itself toxic and thereby poses a health risk to anyone exposed to it.
use of low lead alloys whenever possible, proper control of variables influencing metal/sand penetration and setting up reactions to form lead compounds that minimize leachable
lead in waste material;
Compatibility of Pharmaceutical Products and Contact Materials helps pharmaceutical, toxicology, analytical, and regulatory affairs professionals assess the safety of leachable
and extractable chemicals associated with drug product packaging, manufacturing systems, and devices.
Recently glass polyalkenoate cements formed from poly(acrylic acid) and ion leachable
glasses have been developed as chemically adhesive bone cements.
Compendia tests are required for CCS according to both EMEA and USFDA, but results are limited to the information that can be used to conduct a comprehensive leachable
Although the sparse pattern of drilling does not allow a resource calculation, Billiton's reports refer to the potential for a leachable
resource in excess of 60M mt of greater-than-0.
Another possibility is that contact with the hot metal degrades the binders in cores made from this resin and renders them more leachable
These claims incorporate projected southwestern extensions of the MAN Area copper-zinc-silver-gold sulfide mineralization, as well as the southwestern continuation of the leachable
oxide copper and chalcocite copper deposits overlying the MAN Area sulfide zone.
The Company is expanding its production capacity and advancing the development of the oxide heap leachable
gold and silver historically identified that includes both pre-processed and unprocessed ore.
Based on known leachable
reserves, Nifty's life will exceed 10 yr at the expanded production rate.
Approximately 20,000 feet of the planned and permitted drill program has been designed to further delineate the extent of the leachable
chalcocite resource, and provide additional drill and assay data for an independent NI 43-101 resource estimate to be completed by the end of the year.