The epidermal stem cell factor is over-expressed in lentigo
senilis: implication for the mechanism of hyperpigmentation.
9%) lesions which have a deep brown pigment with thin brown lines at the border, a pattern found in solar lentigo
or Clark nevus
They are: superficial spreading melanoma (SSM), which occurs in about 70% of patients; nodular malignant melanoma (NM), which occurs in about 15% of patients; and lentigo
maligna melanoma (LMM), which occurs in about 15%, in older patients, on the exposed parts of the body on the basis of premalignant melanosis as the result of chronic exposure to sunlight; according to the personal clinical experience of Professor Virag, acral melanomas do not occur on the skin of the head and neck (5).
BRAF mutations is superficial spreading melanoma; the acral, mucosal, uveal, and lentigo
maligna variants usually have a wild-type BRAF.
On histopathological examination of 85 cases, 11 were classical Lichen planus and 09 were its morphological variants (Figure 2); 5 cases of Psoriasis, 5 cases of Prurigo nodularis, 4 cases of Morphea (Figure 3), 4 cases of Lichen simplex chronicus, 3 cases of Lichen striatus, 3 cases of Verruca plana, 3 cases of Becker nevus, 2 cases of Pemphigus foliaceus, 2 cases of Linear epidermal nevus (Figure 4), 2 cases of Macular amyloidosis, 2 cases of Lentigo
simplex, 2 cases of LSEA and one case each of other lesions as shown in Table 1.
The less common subtypes are lentigo
maligna melanomas and acral lentiginous melanomas.
Furthermore, melanin accumulation is directly associated with pigmentation disorders such as melasma, freckles, and solar lentigo
maligna is often a precursor to lentigo
maligna melanoma, a potentially serious form of skin cancer.
The condition is called lentigo
simplex and results in harmless, flat spots.
m (Med) Afeccion cutanea caracterizada por pequenas manchas de color oscuro.
El melanoma superficial es la variedad mas comun, le sigue el melanoma nodular, siendo el melanoma lentigo
maligno menos comun, aunque algunas publicaciones lo consideran como el mas frecuente en cabeza y cuello.
Mas infrecuentes aun son el nevus melanocitico comun adquirido y el nevus de Spitz variante verrugosa, el lentigo
solar y los nevus displasicos (59).