* Most common spectrum is Borderline Tuberculoid-(66.2%) followed by Borderline Lepromatous--10.4%, Pure Neuritic Hansen's--8.5%, Lepromatous
leprosy is a travel-related hazard for travelers to endemic areas.
We report a case of phototoxic dermatitis that spared lepromatous
skin lesions with photo-onycholysis probably induced by SPFX.
Though Tregs in mice express CD25 constitutively, in humans only those with CD25 show suppressive function.10 Leprosy reactions in contrast showed a decrease in Treg cells which paralleled the increase in Th17 population.11 Moreover, there was downregulation of intracellular TGF-[beta].11,12 Most reports showed a reduction in Treg cells in patients with ENL reactions compared with non-reaction lepromatous
He was later confirmed with leprosy on the basis of skin biopsy of these lesions which revealed AFB smear 3+ and was labeled with Lepromatous
leprosy and started on clofazamine and rifampicin.
Comparative cytomorphology of skin, lymph node, liver and bone marrow in patients with lepromatous
Its clinical spectrum ranges from tuberculoid leprosy through borderline forms to lepromatous
leprosy of the Ridley-Jopling classification .
Clinical diagnosis of lepromatous
leprosy was established on the basis of 2 of 3 criteria set by the World Health Organization (WHO) : hypochromic anesthetic skin lesions and palpable peripheral nerves.
Of these, 13 presented indeterminate leprosy (IL), 15 presented tuberculoid leprosy (TT), and 15 presented lepromatous
The infectious causes are Mycobacterium tuberculosis causing tuberculous granulomas both caseating and non caseating, Mycobacterium leprae causing non caseating lepromatous
granulomas both tuberculoid and lepromatous
as well as borderline type, Treponema Pallidum causing Gumma in syphilis a microscopic to grossly visible granulomatous lesion composed of sheets of histiocytes, plasma cell and vasculitis.
The following sociodemographic and clinical information was registered on an evaluation form: age, gender, race, WHO classification (paucibacillary or multibacillary), WHO disability grading (0, 1 or 2), Madrid clinical classification (tuberculoid, borderline or lepromatous
), time since diagnosis, number of neural decompression surgeries performed, pain onset, nerves involved and use of medication for leprosy reaction.
The clinical spectrum proposed by Ridley and Jopling (R&J) consists of two poles: tuberculoid (TT) and lepromatous
(LL), and three intermediate forms: borderline-tuberculoid (BT), borderline-borderline (BB), and borderline-lepromatous (BL).