chauvoei, belongs to the leucocidin
superfamily of bacterial toxins and is not reported in any other clostridia species (FREY et al., 2012).
The production of leucocidins
, such as Panton-Valentine leucocidin
(PVL), and other virulence factors promotes neutrophil lysis and evasion of the immune system, dysregulating the host response and favoring the spread of the infection leading to sepsis (36).
The role of the Panton-Valentine leucocidin
toxin in staphylococcal disease: a systematic review and meta-analysis.
Life-threatening staphylococcal infections are generally caused by the co-presence and combined actions of staphylococcal enterotoxins (sea-sej), toxic shock syndrome toxin-1 (tst-1), exfoliative toxins (eta and etb) and the panton-valentine leucocidin
.  S.
Moreover, virulence factors, such as Panton-Valentine leucocidin
and enterotoxins, have been described in S.
Healthcare-associated transmission of Panton-Valentine leucocidin
positive methicillin-resistant Staphylococcus aureus: the value of screening asymptomatic healthcare workers.
gene carriage among Staphylococcus aureus strains recovered from skin and soft tissue infections in Turkey.
aureus even when MDR or Panton-Valentine leucocidin
positive isolates were present.
A pentaplex PCR assay for the rapid detection of methicillin-resistant Staphylococcus aureus and Panton-Valentine Leucocidin
. BMC Microbiol 2009;9:113.
Its pentone valentine leucocidin
(PVL) positive strain has been associated with necrotizing pneumonia5.
The increased incidence of MRSA in wound infection may be due to the production on Panton Valentine Leucocidin
by MRSA which is shown too associated with tissue necrosis.
Couppie et al., "Panton-valentine leucocidin
and gamma-hemolysin from Staphylococcus aureus ATCC 49775 are encoded by distinct genetic loci and have different biological activities," Infection and Immunity, vol.