Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis
. Br J Haematol 2009; 147:3-12.
There are various unidentified factors in the diet, which may predispose to molecular and chromosomal aberrations leading to leukaemogenesis
. Therefore, it is not a single risk factor, but it may be one of the risk factors which may predispose to leukaemia.
Wang et al., "A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis
," Nature, vol.
AML is a disease of genetic heterogeneity as no single mutation is seen to drive AML yet several mutations have been identified to contribute to leukaemogenesis
. Cytogenetic or chromosomal abnormalities, such as translocations, are reported in 55% of patients with AML .
Reilly, "Pathogenesis of acute myeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis
?" British Journal of Haematology, vol.
Pathogenesis of acutemyeloid leukaemia and inv(16)(p13;q22): a paradigm for understanding leukaemogenesis
? Br J Haematol.
Moreover, the detection and quantification of NPM1m represents a major specific marker for the molecular monitoring of minimal residual disease (MRD) in AML, since it appears as an early initiating event in leukaemogenesis
Murine virus leukaemogenesis
relationship between susceptibility and immunodepression.
(3.) Reilly JT: Class III receptor tyrosine kinases: Role in leukaemogenesis
. Br J Haematol 2002; 116: 744-757
The chromosomal translocation t(15;17) generates the PML/RAR [alpha] fusion gene which plays an essential role in leukaemogenesis
. The most common abnormality in acute promyelocytic leukaemia (APL) is PML/RAR [alpha], however 2 per cent of APL can have other translocations, e.g.