Fibrosis and stenosis of the long penetrating cerebral arteries: The cause of the white matter pathology in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
. Brain Pathol 2004;14:358-64.
Global Markets Direct's, 'Progressive Multifocal Leukoencephalopathy
- Pipeline Review, H1 2016', provides an overview of the Progressive Multifocal Leukoencephalopathy
Differential diagnoses: Global hypoxic/ischemic insult, cerebral vasculopathy, posterior reversible encephalopathy syndrome (PRES), hypoglycemic encephalopathy, progressive multifocal leukoencephalopathy
(PML) and acute disseminated encephalomyelitis (ADEM).
Herein, we describe the first reported Japanese case of reversible posterior leukoencephalopathy
syndrome (RPLS) that developed on receiving sunitinib therapy for metastatic RCC.
They discuss the history of viral infections of the central nervous system, the basics of virology, neuroepidemiology and the epidemiology of viral infections of the nervous system, the clinical approach to the syndromes of viral encephalitis, myelitis, and meningitis, laboratory diagnosis of viral infection, neuroimaging, viral neuropathogenesis, and the neuropathology of viral infections; DNA viruses like the herpes simplex virus, varicella-zoster, the Epstein-Barr virus, cytomegalovirus, human herpesvirus 6, and progressive multifocal leukoencephalopathy
; RNA viruses like West Nile and St.
DISCUSSION: MLC is a rare neurodegenerative disorder characterized by infantile-onset megalencephaly, cerebral leukoencephalopathy
, and delayed onset of slowly progressive neurologic dysfunction.
The diagnosis of CADASIL should be taken into account in patients with lacunar infarcts, leukoencephalopathy
and migraine with an atypical aura even in the absence of white matter lesions in the anterior temporal poles .
Adam began working with personal trainer Jim Haugh after recovering from the infection diagnosed as progressive multifocal leukoencephalopathy
Neurotoxicity, usually characterized by peripheral neuropathies, loss of taste, seizures, leukoencephalopathy
, reversible posterior leukoencephalopathy
syndrome (RPLS), and muscle cramps have been reported.
This condition is also known as reversible posterior leukoencephalopathy
syndrome, reversible posterior cerebral oedema syndrome and reversible occipital parietal encephalopathy.
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
(CADASIL), which is caused by the mutation in NOTCH3 gene, is the most common hereditary small vessel disease of the brain in adults.
Please see the Important Safety Information below including the Boxed Warning regarding fatal infusion reactions, severe mucocutaneous reactions, hepatitis B virus reactivation and progressive multifocal leukoencephalopathy