The compound may potentially be used as a single agent or in combination with currently available lipid-lowering
drugs, and also has potential in the treatment of obesity.
The study found the lipid-lowering
property of pterostilbene to be superior to that of resveratrol, another beneficial compound found in grapes, as well as to ciprofibrate, a commercial hypolipidemic drug.
Participants in the Dutch clinical trial were boys and girls age 8-18 years who had been on a lipid-lowering
diet for at least 3 months at the study's outset; they continued the diet throughout.
There are a number of HIV-specific considerations, for example avoiding interactions of lipid-lowering
drugs with antiretrovirals.
Risk factors include the use of lipid-lowering
drugs, testosterone, or corticosteroids; a history of bodybuilding; or excessive alcohol consumption.
In a recent study from Halifax, NS, Canada, older persons who were taking lipid-lowering
medication (i.e., statins) were found to have a lower incidence of dementia, even with factoring in variables responsible for a healthy lifestyle.
This approach must be taken with caution since PIs interact with some lipid-lowering
drugs known as statins, causing severe and potentially fatal toxicity.
The sub analysis showed a 47 per cent reduction in LDL-C levels among stable coronary artery disease (CAD) patients who remained event-free following aggressive lipid-lowering
therapy with LIPITOR(R) (atorvastatin calcium).
Additional abstracts to be presented include a sub-analysis of the Repatha cardiovascular outcomes study, investigating the effects of triglycerides on cardiovascular risk in patients with established cardiovascular disease, and an evaluation of the utilization of lipid-lowering
therapies in patients at high risk for cardiovascular events in a real-world setting.
The benefits of low LDL cholesterol have been firmly verified in clinical trials of statins and other lipid-lowering